1 / 1

Designing Novel Chiral Ligands for Catalysis: Combining Rigidity and Steric Modulation

Explore the synthesis of chiral ligands with conformational rigidity and adjustable steric properties for enhanced catalytic applications. Discover structural variations on diphosphines from optically active compounds.

season
Download Presentation

Designing Novel Chiral Ligands for Catalysis: Combining Rigidity and Steric Modulation

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Ni(CO)4 + P-P (PP)Ni(CO)2 + 2 CO BITIOP DPPB R=H (DPPB)Ni(CO)2 (BITIOP)Ni(CO)2 R,R Pd(PhCN)2Cl2 Ni(CO)4 b' a b a' Cs -38.98 ppm -1.75 ppm b a H2 H2 H2 e.d.% = 43% e.e.% = 70% Conf = R/R Conv % = 100% (55h) e.e. % = 66% (Ar = C6H5) e.e. % = 64% (Ar = C8H9) Conf = R conv (%) = 100% α+β/l = 60/40 α/β = 67/33 lin Structural variations on chiral ligands: new chelanting diphosphines from optical active (1,4)-(Z)-2-butenes. E. Cesarotti, I. Rimoldi, P. Spalluto Università degli Studi di Milano, Facoltà di Farmacia, Dipartimento di Chimica Inorganica, Metallorganica e Analitica. Another essential feature: the modulation of the ligand steric properties by the modification of the substituents on the stereogenic atoms versus An essential feature: the conformational rigidity of the ligand Is it possible to prepare a ligand gathering the conformational rigidity of an atropisomeric ligand with the possibility to modulate steric properties by the modification of the substituents on the stereogenic atoms? TsCl NaOH enzymatic resolution by LAK Vinyl acetate Commercial available mixture S,S S,S Ar2PLi -78°C S,S e.e.% > 98% meso R,R Work in progress: R=(CH3)2CH-, C6H11-, C6H5-

More Related