Vorinostat - PowerPoint PPT Presentation

The Emerging Role of Epigenetics in Human Diseases

The Emerging Role of Epigenetics in Human Diseases. David P. Gardner, Ph.D. Professor of Biochemistry. Objectives. Provide a working definition of epigenetics and contrast an epigenetic change with a mutation.

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1.14k views • 32 slides

% of cells with &gt;4N DNA content

30. MDA-MB-468. MDA-MB-231. 25. 20. % of cells with &gt;4N DNA content. 15. 10. 5. 0. 0. 20. 50. 100. 250. nM, MK-0457, 48hr. Online Resource 1. Online Resource 2. MDA-MB-468. Aurora B. Merge. Alpha Tubulin. Control. 20 nM MK-0457. 50 nM MK-0457. 100 nM MK-0457. 10 μ m.

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116 views • 4 slides

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Vorinostat - PowerPoint PPT Presentation

The Emerging Role of Epigenetics in Human Diseases

% of cells with &amp;gt;4N DNA content

% of cells with >4N DNA content