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PTH related disorders

PTH related disorders

PTH related disorders. Simona Glasberg, MD Neuroendocrine Tumors Unit, Endocrinology & Metabolism Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. Course in Endocrinology, Year 4, HUJI, 31/10/2013. Introduction - The parathyroid glands.

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895 views • 69 slides
Current Status of Surgery For Primary and Secondary Hyperparathyroidism

Current Status of Surgery For Primary and Secondary Hyperparathyroidism

Current Status of Surgery For Primary and Secondary Hyperparathyroidism. Surgery Grand Rounds 20 Aug., 2014 W. G. Schenk III. Disclosures. HYPERPARATHYROIDISM. Basic Physiology, Anatomy, Embryology Primary Hyperpara Clinical Presentations

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885 views • 47 slides
Current Status of Surgery For Primary and Secondary Hyperparathyroidism

Current Status of Surgery For Primary and Secondary Hyperparathyroidism

Current Status of Surgery For Primary and Secondary Hyperparathyroidism. Surgery Grand Rounds 20 Aug., 2014 W. G. Schenk III. Disclosures. HYPERPARATHYROIDISM. Basic Physiology, Anatomy, Embryology Primary Hyperpara Clinical Presentations

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771 views • 47 slides
Metabolic Bone Disease

Metabolic Bone Disease

Metabolic Bone Disease. Douglas Stahura DO 19 March 2002. Overview. Normal bone undergoes constant remodeling: Production of organic matrix (osteoblasts) Matrix maturation Mineralization of mature matrix Osteoclastic resorption of mineralized bone. Overview.

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1.27k views • 37 slides
הגישה להיפוקלצמיה

הגישה להיפוקלצמיה

הגישה להיפוקלצמיה. ד"ר ורדה אשד מכון אנדוקריני – מרפאה מטבולית בי"ח בילינסון. אישה בת 70 Ca - 8mg/dl נמצא במהלך בירור שעשתה לאוסטיאופורוזיס. מופנית לבירור מרפאתי. תלונות על כאבי עצמות וחולשה. Alb-4, ALP-156. אישה בת 60 Ca – 6.4mg/dl

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731 views • 35 slides
Parathyroid Hormone

Parathyroid Hormone

Parathyroid Hormone. ENDO BLOCK 412. Dr. Shaikh Mujeeb Ahmed Assistant Professor AlMaarefa College. Lecture Objectives. At the end of this lecture the student should be able to Describe the role of calcium in the body Enumerate the factors affecting plasma calcium

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759 views • 30 slides
Parathyroid hormone(Parathormone) Lecture NO: 2 nd MBBS

Parathyroid hormone(Parathormone) Lecture NO: 2 nd MBBS

Parathyroid hormone(Parathormone) Lecture NO: 2 nd MBBS. Dr Muhammad Ramzan. Parathyroid hormone (PTH) – the definition. A protein hormone (84 AA.) from the Parathyroid gland that regulates the metabolism of : Calcium and phosphorous in the body It is also called as Parathormone (PTH)

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463 views • 30 slides
Biochemistry of Bone

Biochemistry of Bone

Biochemistry of Bone. Bones contain both organic and inorganic material. The organic material is mainly protein i.e. type – I collagen, comprising 90-95% of organic material. Type – V collagen is also present in small amounts, as are number of non- collagen proteins.

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689 views • 28 slides
Calcium Homeostasis

Calcium Homeostasis

Calcium Homeostasis. Calcium Homeostasis. 99% body calcium in skeleton 0.9 % intracellular 0.1% extracellular 50% bound Mostly albumin (alkalosis) Smaller amount phosphorous and citrate. Calcium Regulation. PTH 4 parathyroid glands Release PTH in response to drop in serum calcium

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774 views • 22 slides
Calcium Homeostasis

Calcium Homeostasis

Calcium Homeostasis. Ihab Samy Lecturer of Surgical Oncology National Cancer Institute Cairo University 2010. Facts About Calcium. Date of Discovery: 1808 Discoverer: Sir Humphrey Davy Name Origin: From the latin word calcis (lime) Uses: life forms for bones and shells

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650 views • 22 slides
PARATHYROID HORMONE, HYPERPARATHYROIDISM CKD, & PTH ASSAYS

PARATHYROID HORMONE, HYPERPARATHYROIDISM CKD, & PTH ASSAYS

PARATHYROID HORMONE, HYPERPARATHYROIDISM CKD, & PTH ASSAYS. David Plaut & Shanti Narayanan Summer, 2012. Parathyroid Hormone - PTH. PTH is a hormone secreted by the Parathyroid gland. There are four Parathyroid glands located behind the thyroid. Role of PTH – To Regulate Calcium Levels.

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642 views • 22 slides
Drugs for osteoporosis (download the lecture from skilltest.co )

Drugs for osteoporosis (download the lecture from skilltest.co )

Drugs for osteoporosis (download the lecture from www.skilltest.co.in ). Dr. Sarvesh Singh Associate Professor Dept. of Pharmacology KGMU, Lucknow E-mail-drsarveshsingh@gmail.com. PLASMA CALCIUM LEVEL. Regulated by 3 hormones: P arathormone (PTH ) Calcitonin

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201 views • 18 slides
Examples 1 - 4

Examples 1 - 4

Examples 1 - 4. Lecture L2.2. Example 1a. // Example 1a: Turn on every other segment on 7-seg display # include <hidef.h> /* common defines and macros */ # include <mc9s12dp256.h> /* derivative information */ # include "main_asm.h" /* interface to the assembly module */

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299 views • 16 slides
Milk-Alkali Syndrome and Evaluation of Hypercalcemia

Milk-Alkali Syndrome and Evaluation of Hypercalcemia

Milk-Alkali Syndrome and Evaluation of Hypercalcemia. Morning Report 8/18/2009 TJ O’Neill. Hypercalcemia. Occurs when entry of Calcium (from GI tract and bone) exceeds rate of loss (urine loss and bone deposition) Should be confirmed with albumin level and preferable ionized Ca.

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384 views • 14 slides
Reduced VDR activation in CKD

Reduced VDR activation in CKD

ESPERIENZA CLINICA SULL'USO DEL PARACALCITOLO ORALE NEI PAZIENTI CON IRC STADIO 3-5 IN TERAPIA CONSERVATIVA S. Di Stante, H. Kulurianu , F. Manenti , M. Marani , M. Martello, M. Di Luca UOC Nefrologia e Dialisi AO Ospedali Riuniti Marche Nord P.O Ospedaliero “S. Salvatore” Pesaro.

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257 views • 13 slides
Nephrology Grand Rounds

Nephrology Grand Rounds

Nephrology Grand Rounds. 5/13/08. Refractory Hyperparathyroidism. Brad Weaver. Causes of refractory HPTH. Inadequate therapy Persistent hyperphosphatemia Acquired abnormalities of parathyroid gland

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275 views • 13 slides
Secondary Hyperparathyroidism in CKD: Usefulness of VDR Agonists

Secondary Hyperparathyroidism in CKD: Usefulness of VDR Agonists

Secondary Hyperparathyroidism in CKD: Usefulness of VDR Agonists. Reference: Sprague SM, Coyne D. Control of secondary hyperparathyroidism by vitamin d receptor agonists in chronic kidney disease. Clin J Am Soc Nephrol . 2010;5:512–518. Introduction: SHPT in CKD.

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412 views • 11 slides
Paricalcitol and calcitriol therapeutic effects, prospective comparison of adult hemodialysis patients

Paricalcitol and calcitriol therapeutic effects, prospective comparison of adult hemodialysis patients

This study aimed to compare the efficacy of a selective activator of the Vitamin D Receptor (VDR) paricalcitol with calcitriol, for the repression in terms of intact Parathyroid Hormone (iPTH) secretion. A comparative study was undertaken in order to determine whether paricalcitol provides a therapeutic advantage to calcitriol. The groups has formed adult hemodialysis individuals treated with dialysis solution three times (4 hours, each seans) per week for 8 months with 1.25 mmol/L calcium (Ca) bicarbonate dialysate. Patients with iPTH levels over 400 pg/ml were treated with paricalcitol. In addition, their iPTH levels over 295 pg/ml were treated with calcitriol. The treatment was cut of both paricalcitol and calcitriol over CaxP > 65 and iPTH <295 pg/mL. The cure was regulated according to levels iPTH in patients both paricalcitol and calcitirol. The application was a rule as particular posthemodialysis. The patients were administered intravenosus paricalcitol 5-10 mcq and calcitriol 1-2 mcq as bolus. Diet restriction was referenced to reduce P levels. All the patients have been screened with parathyroid gland ultrasound and parathyroid scintigraphy. Compared to initial value we achieved 39.3% reduction in the group 2 iPTH concentration (569 pg/mL to 345 pg/mL). On the other hand iPTH concentration has been identified as 337 pg/mL initially while the mean value was 357 pg/mL at the study end of in the group1. In other words the mean average iPTH values is not reduced in group1. These results between Group 1 and Group 2 was statistically significant. As a result paricalcitol much more rapidly and meaningful to reduced according to calcitriol of iPTH levels in serum. On the other hand we have not found difference between two groups with minimal advers effect.

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93 views • 6 slides
TSQ Vantage

TSQ Vantage

Multiplexed LC-MS/MS SRM assay for parathyroid hormone (PTH) and variants: Correlation with current clinical immunoassay methods.

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150 views • 1 slides
After

After

Tenofovir/FTC. Low Vitamin D. 50. 200. 200. Decreased Whole-body Calcium. 40. 150. 150. PTH pg/ml. 30. PTH pg/ml. Percentage. Kidney Damage (Fanconi-like Syndrome). 20. 100. 100. Decreased Bone Mineral Density. Increased PTH. 10. Increased Excretion of Phosphate. 50. 50.

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129 views • 1 slides

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