'Pml rar' presentation slideshows

Chromosome Abnormalities and Their Molecular Correlates in Acute Leukemia

Chromosome Abnormalities and Their Molecular Correlates in Acute Leukemia. SAI-JUAN CHEN State Key Laboratory of Medical Genomics Shanghai Institute of Hematology, Ruijin Hospital Shanghai Second Medical University(SSMU). Development of Classification of Acute Leukemia.

913 views • 64 slides

Molecular Pathogenesis of Leukemia

Type I mutations. Type II mutations. Mutations that affect proliferation/survival. Mutations that impair differentiation. BCR-ABL. PML/RAR a. PDGFR b. PLZF/RAR a, etc. AML1/ETO CBF b /SMMHC TEL/AML1 Other transloc. Flt3 ITD or mutation. C-KIT mutation. MLL translocations.

714 views • 44 slides

Severe coagulopathy

Acute promyelocytic leukemia. Severe coagulopathy. Striking sensitivity to anthracyclines. TAILORED DIAGNOSIS AND MANAGEMENT. Response to differentiating agents (RA, ATO). Specific genetic lesion. M2. M1. M5. M3. PML/RAR. RAR/PML. fusion gene. fusion gene. PML locus.

511 views • 37 slides

Fusion Genes in Cancer Wednesday, June 27th

Fusion Genes in Cancer Wednesday, June 27th. Outline: Transcription Fusion genes Examples of fusion genes in cancer Summary and conclusions. Chromosomes and Genes. In humans, every somatic cell has 23 pairs of chromosomes for a total of 46 chromosomes

369 views • 26 slides

Retinoic Acid Receptor-Alpha and Its Role in Acute Promyelocytic Leukemia

Retinoic Acid Receptor-Alpha and Its Role in Acute Promyelocytic Leukemia. By Alex Sheng. What is Retinoic Acid?. The most biologically active retinoid Derived from Vitamin A. What Does Retinoic Acid Do in the Organism?. Effect of RA on the hindbrain Normal CNS

487 views • 25 slides

APML

780 views • 20 slides

Retinoic Acid Receptor- ? (RAR ? ) & its role in Acute Promyelocytic Leukemia (APL)

Retinoic Acid Receptor- ? (RAR ? ) & its role in Acute Promyelocytic Leukemia (APL). Danielle Matsushima. Vitamin A to Retinoic Acid (RA). Vitamin A is important for many biological processes: transcription, immune function, vision, embryonic development (axis patterning), skin health etc.

582 views • 14 slides

Retinoic Acid Receptor Alpha and Acute Promyelocytic Leukemia

Retinoic Acid Receptor Alpha and Acute Promyelocytic Leukemia. Nidhi Thapar April 1, 2004. Acute Promyelocytic Leukemia. Proliferation of immature blood cells 10,600 new cases of AML each year. Most patients with APL achieve a complete remission when treated (with ATRA).

287 views • 13 slides

HIPK2

a PML. Input. IgG. IP:. WB:. HIPK2. a HIPK2. a PML. PML/RAR a. +. Flag-HIPK2. PML/RAR a.

149 views • 1 slides