'Lkb1' presentation slideshows

Peutz-Jeghers Syndrome and LKB1/STK11

Peutz-Jeghers Syndrome and LKB1/STK11. Kathryn Satterfield. THE DISEASE. Intestinal polyposis Increased risk of cancer in the gastrointestinal tract and reproductive organs Pigmented spots on the skin. Autosomal Dominant.

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LKB1

a. I- Sce I. I- Sce I. I- Sce I. TRE site. TRE site. c. b. Cell fractionation. > 200 copies of TRE/I- Sce I. Chro.ppt. Cyto. Nuc. U2OS/TRE/I -Sce I-19. Electroporation. LKB1. +GFP-KU70/80 or -LKB1. b -actin. +Cherry- tTA -ER. 6 h. +I- Sce ?. EGFR. + Tamoxifen. PARP1.

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Supplemetal Fig. 1

LKB1. -. +. pAMPK(T172). HA-AMPK. FLAG-LKB1. LKB1. -. +. pAMPK(T172). AMPK. pACC(S79). FLAG-LKB1. Supplemetal Fig. 1. B. A. C. LKB1iSP. -. +. -. -. +. -. GFPRNAi. -. -. +. -. -. +. 2DG (20 mM). -. -. -. +. +. +. pAMPK(T172). AMPK. LKB1. Supplemetal Fig. 2.

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