'Increasing oxidative stress appears' presentation slideshows

Cardioprotective effects of vitamin E, morin, rutin and quercetin against Doxorubicin induced oxidative stress of rabbit

Doxorubicin (Adriamycin) is a potent chemotherapeutic agent for the treatment of a variety of human malignancies. Among several different mechanisms proposed for explaining the pathogenesis, increasing oxidative stress appears to play a major model that has been shown to increase free radical producing and decrease activities of endogenous antioxidant enzymes.There is an early depression in glutathione enzymes such as reduced glutathione, glutathioneperoxidase and glutathione-s-transferase. Cardiomyopathy is also associated with apoptosis which precede the development of cardiotoxicity and congestive heart failure. Many different approaches have been used to minimize the incidence of doxorubicin-induced cardiomyopathy. In the present study, the rabbit model, the development of cardiomyopathy was prevented by reducing oxidative stress using natural antioxidant vitamin E (50 IU/kg body weight) and flavonoids morin, rutin and quercetin, which are generally available in the natural diet.

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