100+ Endoplasmic reticulum er stress PowerPoint (PPT) Presentations, Endoplasmic reticulum er stress PPTs

Endoplasmic reticulum er stress - PowerPoint PPT Presentation

Nicardipine induces apoptosis via IRE1 activation in the PC12 cells

Although an endoplasmic reticulum (ER) induction by calcium-channel blocker has been reported, the mechanism of ER stress-mediated apoptosis by nicardipine is unknown. Here, we demonstrated induction of apoptosis by nicardipine in PC12 cells. It was accompanied by the formation of apoptotic bodies via activation of ER-stress sensor, inositol-requiring enzyme 1 (IRE1). IRE1 induces the downregulation of key anti-apoptotic Bcl-2 expression in apoptosis. However, the altered expression of ER chaperones was not observed following nicardipine treatment. The results suggest that insight into the molecular mechanisms underlying nicardipineinduced apoptosis may facilitate the reduction of side effects and active treatment.

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90 views • 4 slides

Role of Endoplasmic Reticulum Stress in Mechanism of Action of Antitumor Quinols.

PMX 8098. Gene expression changes (>2) in HCT116 cells in response to PMX 290. ER Tracker. 4 3 2 1 0 -1 -2 -3 -4. Change in expression (LOG2). Merge. DDIT3 TRIB3 ASNS C20orf139 UPP1 DNAJB9 FGF19 DDIT4 SQSTM1 ATF3 GDF15 BIRC3 SLC7A11 MAP1LC3 PRO618 PPP1R15A KIAA1718

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441 views • 1 slides

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Endoplasmic reticulum er stress - PowerPoint PPT Presentation

Nicardipine induces apoptosis via IRE1 activation in the PC12 cells

Role of Endoplasmic Reticulum Stress in Mechanism of Action of Antitumor Quinols.