'C3 convertase' presentation slideshows

? 5 ? ???? ( complement system)

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THE COMPLEMENT SYSTEM

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The Complement System

The Complement System. Historical Background. Pfeiffer:- Lysis of Cholera bacilli - Demonstration of heat liability Bordet: Confirmed the observations and called the substance Alexine Ehrlich : Introduced the term Complement. Introduction.

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THE COMPLEMENT SYSTEM

THE COMPLEMENT SYSTEM. THE COMPLEMENT SYSTEM. The complement system is a set of plasma proteins that act in a cascade to attack and kill extracellular pathogens . Approximately 30 components : activating molecules regulator factors complement receptors

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Topic 6 - Evolution of Immune Systems & Protostome Immunity

Topic 6 - Evolution of Immune Systems & Protostome Immunity Recurrent themes in comparative immunology: Gene duplications lead to diversified functions Evolutionarily related molecules can assume distinct functions - divergent evolution Unrelated molecules can develop similar functions

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Complement

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3RD SEMINAR

3RD SEMINAR. INNATE IMMUNITY : ANTIVIRAL STATE, KILLER CELLS, THE COMPLEMENT SYSTEM. DANGER SIGNALS ARE TRANSLATED TO CYTOKINE SECRETION THROUGH VARIOUS MOLECULAR SENSORS IN DC SUBTYPES. 4. 6. 6. 2. 1. 1. NLR. RLR. RLR. IL-1 ? IL-12/23 IL-10. IFN ? IFN ?. 5. 10. 7. 3. 9. 7.

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Janeway 9.49 part 2

Janeway 9.49 part 2. Roitt 12.22. Roitt 4.1. A Cascade of Proteases Is A Biological Amplifier. Protease cascades as biological amplifiers. Ucker, 2000. Classical Activation Pathway. C4b. C3b. The Classical Activation Pathway. The small fragments act as soluble mediators. C3a. C2b.

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BIOT 307 MOLECULAR IMMUNOLOGY

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Janeway 9.49 part 2

Janeway 9.49 part 2. Roitt 12.22. Roitt 4.1. Classical Activation Pathway. C4b. The Classical Activation Pathway. Some small fragments act as soluble mediators. C5a. C3a. C4a. C2b. C3. C5. C6. C7. C8. C9. C2. C4. C1s. C1. Ab. C5b. C6. C7. C2a. C3b. C8. C9. C4b.

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Chapter 6 The Complement System

Chapter 6 The Complement System. Complement System. Major effector branch of humoral immune system in vertebrates However, invertebrates possess proteins related to complement system Even sea urchins have complement. Functions of Complement. 7 Functional Categories:

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Complement and Mediators of Inflammation

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COMPLEMENT

COMPLEMENT. Anna Tjandrawati Clinical Pathology Department Medical Faculty Padjadjaran University Hasan sadikin General Hosptital Bandung. COMPLEMENT. Definition : a system comprised of a groups of plasma and cell membrane proteins that play an important role in

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welcome

welcome. DHANAJI NANA MAHAVIDYALAYA,FAIZPUR DEPARTMENT OF MICROBIOLOGY The Complement System Miss. Suvarna D. Patil. Overview. The complement system is part of the innate immune system ( vs adaptive)

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Compl e ment

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Innate Defenses Complement

Innate Defenses Complement. The complement system is a biochemical cascade that helps clear pathogens from an organism It is part of the innate immune system The complement system consists of a number of small proteins found in the blood, normally circulating as inactive zymogens

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COMPLEMENT SYSTEM

COMPLEMENT SYSTEM. Elainne Kesuma (1-4206-005) Harvianto Siman Santosa (1-4206-033). Photo Courtesy: Widhi Nugraha Sutedjo. COMPLEMENT SYSTEM. Series of Protein which amplify response function of body toward infection, through innate and adaptive immunity

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nrneph.2012.213 pf2

Figure 2 Activation of C3 convertase is involved in both complement-mediated and immune-complex-mediated MPGN. Bomback, A. S. & Appel, G. B. (2012) Pathogenesis of the C3 glomerulopathies and reclassification of MPGN Nat. Rev. Nephrol. doi:10.1038/nrneph.2012.213.

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