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Host-guest complexation of melatonin with p-sulfonated calix[6]Arenes

Host-guest complexation of melatonin with p-sulfonated calix[6]Arenes

The complex characteristics of p-sulfonated calix [6] arene (SC6A) and Melatonin (MLT) were examined through spectrofluorimetry, 1HNMR spectroscopy and molecular modeling calculations. The fluorescence of MLT significantly quenched upon the addition of SC6A, which revealed the formation of inclusion complexes between MLT and SC6A. The stoichiometric ratio of 1:1 was obtained via the continuous variation method. The experimental results show that SC6A forms at least 1000 times stron- ger inclusion complexes with MLT than u201au00f1CD and CB[7], which have the similar size of the cavity. The 1HNMR spectra verified that the MLT may be partially penetrated into the hydrophobic cavity of SC6A. This finding was also confirmed by density functional theory calculations.

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Synthesis and antimicrobial studies of some new Substituted 3-arylidene-2-methylpyrazolo[5,1-b]quinazolin-9(3H)-ones

Synthesis and antimicrobial studies of some new Substituted 3-arylidene-2-methylpyrazolo[5,1-b]quinazolin-9(3H)-ones

Synthesis of substituted 3-arylidene-2-methylpyrazolo[5,1-b]quinazolin-9(3H)-ones [4a-t] is attempted by the condensation of aromatic aldehydes [3a-d] with 2-methylpyrazolo[5,1-b]quinazolin-9(4H)-ones [2a-e] in the presence of piperdine. 2a-e were obtained by azeotropic distillation of 3-methyl-1H-pyrazol-5(4H)-one and 1Hbenzo[d][1,3]oxazine-2,4-diones [1a-e]. The structures of synthesized compounds are confirmed by IR and 1HNMR, 13CNMR and mass spectral studies. Further, they were screened in vitro for antibacterial activity against Escherichia coli and Salmonella typhi. Antifungal activity is evaluated against Aspergillus niger and Penicillium chrysogenum using Paper disc diffusion method. Some of the compounds were found to exhibit promising antibacterial and antifungal activities.

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