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This resource provides an overview of syndromal children, focusing on key definitions and classifications such as malformations, deformations, disruptions, sequences, and syndromes. It explains malformations as morphological defects due to abnormal developmental processes, like cleft lip. Deformations are defined as abnormal body part forms caused by mechanical forces late in fetal development, while disruptions are defects arising from interference with normal growth processes, illustrated by examples such as amniotic bands leading to amputations.
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1. The Syndromal Child Michael Underbrink, MD
Ronald Deskin, MD
2. Definitions Malformation
Deformation
Disruption Sequence
Syndrome
Association
3. Malformation a morphologic defect of an organ, part of an organ, or larger area of the body resulting from an intrinsically abnormal developmental process
e.g., cleft lip
4. Deformation abnormal form or position of a body part caused by nondisruptive mechanical forces
Usually late in fetal development
Mechanical, malformational or functional
e.g., Potter
5. Disruption defect of an organ, part of an organ, or a larger area of the body due to interference with a normal process
Sporadic and rare
e.g., anmiotic bands leading to amputations
