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Life Sciences Efficiency

Life Sciences Efficiency. Mario Philips. Derek Pendlebury. Marketplace Dynamics. Semiconductor…or Life Sciences? Development costs escalating Margins under pressure High purity products with high safety profiles Global customers Niche products with high associated costs

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Life Sciences Efficiency

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  1. Life Sciences Efficiency Mario Philips Derek Pendlebury

  2. Marketplace Dynamics • Semiconductor…or Life Sciences? • Development costs escalating • Margins under pressure • High purity products with high safety profiles • Global customers • Niche products with high associated costs • Multi-product manufacturing sites • Highly complex/regulated manufacturing • Selection of partner = Right technology / Quality

  3. ATMI…and Life Sciences… • Semiconductor and Life Sciences/Bio-Pharma share the need for… • High purity • Materials integrity • Reduced fixed costs and capital spending • Shortening production runs • Reliable, repeatable production • More process automation • Higher productivity

  4. ATMI…and Life Sciences… • ATMI’s semiconductor materials packaging expertise fits Life Sciences • Life Sciences one-time use/disposable market about a decade behind semiconductor • No process is more demanding than semiconductor; pharma is “easier” • Expertise handling, storing, delivering critical materials reliably • Understand interactions of materials with packaging • Know how to sell value of disposables into risk-averse industry

  5. Biotech Process Flow One-time Use Opportunity Stainless Steel Process, schematic Disposable Process, schematic ATMI ATMI Bioreactor ATMI ATMI ATMI

  6. ATMI Disposable Technologies Solve Key Issues • Disposable alternative to fixed stainless steel manufacturing systems • Faster development and production cycles • Quicker time to market • Rapid process changeover • Ensure materials integrity across “multi-product” manufacturing facilities • Increase throughput and improved facility utilization • Reduced capital investment

  7. ATMI Advantage • Build on more demanding semiconductor experience of materials and packaging interface/high throughput science expertise • Process efficiency focus and the strongest technology range in mixing and containment, positioned in all stages of product development • Benchmark mixing technology to the market • Immediately available scalable technology for one-time use process vessel applications like mixing, contained storage and bioreactors • Direct control of own film production = unique in BioPharm

  8. Case Study • Cost Efficiencies • Traditional: Stainless Steel (cost per batch) • Consumables - $4000Process Set-up Time/Labor - $5775 • Depreciation - $60 • Annual cost: $2.95 million Cost per batch: $9835 • New: Disposable (cost per batch • Consumables - $1000 • Process Set-up Time/Labor - $1925 • Depreciation - $40 • Annual cost: $0.89 million Cost per batch: $2965 • Efficiency Gain >300% Pharmaceutical Manufacturer, NJ • 1000L mixing @ 300 batches per year. Porcine skin rafts suspensions • Process Efficiencies • Traditional: Stainless Steel • per Shift 2 • per Year 427 • New: Disposable • Per Shift 6 • Per Year 1280 • Efficiency Gain 300%

  9. Market Overview • 25% CAGR biotechnology market for • Sterile fluid storage and containment • Mixing and blending • Bioreactor and fermentation • Growth • Expanding, quality-demanding market • Disposables heavily adopted in all new facilities, retrofitted into existing ones • 81% of customers specify single use in new processes • Technology-driven disposable solutions • Huge opportunities for focused suppliers

  10. Impact on ATMI LifeSciences Revenue Other opportunities in LifeSciences • Mammalian Cell Culture • Storage • Fermentation • Dispensing Other markets • Traditional Pharma • Cosmetic / Dermal

  11. Q&A

  12. ATMI, the ATMI logo, AccuDose, AutoClean, Better Process. Delivered., Cerulean, EPM, ErgoNOW, GasGauge, IDEAL Clean, LOK cap, NOWPak, NOWTrak, PDMPak, ProAct, the ProAct logo, ProE-Vap, RegenSi, SAGE, The Source of Process Efficiency, TiTaN Kleen, UniChem and VAC are trademarks or registered trademarks of Advanced Technology Materials, Inc. in the United States, other countries or both. SDS is a trademark or registered trademark of Advanced Technology Materials, Inc. and Matheson Gas Products, Inc. in the United States, other countries or both. Other company, product, or service names may be trademarks or service marks of others.

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