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## Low risk n =91 Median survival 17.5 years

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**Supplemental figure 1.**Survival data among 614 Mayo Clinic patients with primary myelofibrosis risk-stratified by the International Prognostic Scoring System (IPSS) (from time of within one year of diagnosis) Survival Low risk n=91 Median survival 17.5 years P<0.001 Intermediate-1 risk n=161 Median survival 6.8 years High risk n=212 Median survival 2 years Intermediate-2 risk n=150 Median survival 4.6 years Years**Supplemental figure 2.**Survival data among 614 Mayo Clinic patients with primary myelofibrosis risk-stratified by the Dynamic International Prognostic Scoring System (DIPSS) (from time of within one year of diagnosis) Survival Low risk n=91 Median survival 17.5 years Intermediate-1 risk n=225 Median survival 6.3 years High risk n=69 Median survival 1.5 years Intermediate-2 risk n=229 Median survival 2.7 years P<0.001 Years**Supplemental figure 3.**Survival data among 584 Mayo Clinic patients with primary myelofibrosis risk-stratified by the Dynamic International Prognostic Scoring System (DIPSS)-plus (from time of within one year of diagnosis) Survival Low risk n=76 Median survival 19.2 years Intermediate-1 risk n=116 Median survival 8.1 years High risk n=195 Median survival 1.7 years Intermediate-2 risk n=197 Median survival 4.7 years P<0.001 Years