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Integrative approach for drug discovering

Integrative approach for drug discovering. G. P. S. Raghava, Head Bioinformatics Centre, Institute of Microbial Technology, Chandigarh. In-Silico Approaches Bioinformatics: Searching drug targets Chemo/Pharma Informatics: Inhibitors against targets Experimental Approaches

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Integrative approach for drug discovering

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  1. Integrative approach for drug discovering G. P. S. Raghava, Head Bioinformatics Centre, Institute of Microbial Technology, Chandigarh In-Silico Approaches Bioinformatics: Searching drug targets Chemo/Pharma Informatics: Inhibitors against targets Experimental Approaches Biology: Bioassays for testing, In vivo testing Chemistry: Synthesis of chemicals

  2. Progress in Expermental Biology

  3. Challenges and Expectations from OSDD Chemistry Group In silico models against multiple targets Models for cell lyses Models for ADEMT Select common molecules satisfy all requrement Generate analogs of common molecules Repeat step 1 to 5 to search best molecules Synthesis of chemicals (Limitations, need help) Experimentally measure efficacy of chemical Use experimental data for model improvement Repeat step 1 to 9 till get desired drug molecule

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