1 / 3

Advanced Liver Drug Metabolism Studies Using 3D Cell Models

Explore the role of the liver in drug metabolism through in-depth studies of hepatocytes, sinusoids, and matrigel-based constructs. Discover how computer-aided 3D free-form fabrication can enhance pharmacokinetic models. Enhance your understanding of liver functions and create advanced experimental models for drug testing.

rozene
Download Presentation

Advanced Liver Drug Metabolism Studies Using 3D Cell Models

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Journal Club2 Olga Filippova, Munir Nahri, Akash Patel Group 1

  2. Liver Introduction • Lobules • Functional Unit • Vascular Triads • Hepatocyte Plate Sinusoids

  3. Intro to Liver – sinusoids, hepatocyte role in drug metabolism, urea’s connection to drug metabolism, endothelia – hepatocyte signaling for drug metabolism • Matrigel – composition (IV, laminin), pros (thermal crosslinking, differentiation) + cons (low shear + young’s, little proliferation), • Current Trends - Free-form fabrication (computer aided for reproducibility, mass printing), • Hypothesis – computer aided 3D free-form fabrication of co-cultured cell-laden Matrigel constructs for improved in vitro pharmacokinetic model • Control (AH, AHE), Experimental (MH, MHE) • Temperature controlled environment is necessary for proper matrigel printing • Improving a current model • Intro to Paper – similar alginate model but only H, simple diagram,

More Related