'Drug metabolism' presentation slideshows

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Gastrointestinal System

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Pharmacogenomics

Pharmacogenomics. Eric Jorgenson. Outline. Introduction Pharmacogenetics TPMT CYP2D6 Pharmacogenomics GWAS Gene Expression. What is Pharmacogenetics?. The study of the role of inheritance in the individual variation in drug response. Efficacy Toxicity.

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Factors Involved In Drug Activity

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Pharmacotherapeutic Considerations in the Elderly

Pharmacotherapeutic Considerations in the Elderly. Melanie A. Dodd, Pharm.D., Ph.C., BCPS Assistant Professor of Pharmacy in Geriatrics College of Pharmacy The University of New Mexico. OBJECTIVES. At the conclusion of the lecture the student shall be able to:

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Geriatric Pharmacotherapy

Geriatric Pharmacotherapy. Objectives. Understand key issues in geriatric pharmacotherapy Understand the effect age on pharmacokinetics and pharmacodynamics Discuss risk factors for adverse drug events and ways to diminish them Understand the principles of drug prescribing for older patients.

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DESIGN OF A NOVEL ANXIOLYTIC AND ANTIDEPRESSANT AGENT

DESIGN OF A NOVEL ANXIOLYTIC AND ANTIDEPRESSANT AGENT. meta -Chlorophenylpiperazine (mCPP). Target - Serotonin Receptor. Notes Important receptor in central nervous system 7 types (5-HT 1 - 5HT 7 ) and 14 subtypes G-Protein-coupled receptors (except 5-HT 3 )

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NIGMS Training in Systems & Integrative Science

NIGMS Training in Systems & Integrative Science. Peter C. Preusch, Ph.D. Program Director Pharmacological Sciences Training Grant Program, NIGMS, NIH . LSRO Meeting Bethesda Marriott Hotel October 20-21, 2002. NIGMS and NIH Predoctoral & Postdoctoral Training in FY2001. Total U.S. BiolSci

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Collated by Maria Fitzgerald Biosciences Translational Coordinator

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CH 19 FOOD-DRUG INTERACTIONS

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Pharmacokinetics

Pharmacokinetics. Elimination. Pharmacokinetics (PK). The study of the disposition of a drug The disposition of a drug includes the processes of ADME - A bsorption D istribution M etabolism E xcretion. ADME. Importance.

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Training Our Future Colleagues and Successors

Training Our Future Colleagues and Successors. Preparing residents for 2005-2040 Much depends on the impact of: Changing demographics The Human Genome Minimally invasive procedures. Changing Demographics in the U.S. Immigration More high-risk obstetrics

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Bioanalytical Chemistry 22 nd March, 2011

DRUG Metabolism and toxicity Umesh M. Hanumegowda MVSc PhD DABT Discovery Toxicology Bristol-Myers Squibb, Wallingford, CT. Bioanalytical Chemistry 22 nd March, 2011. DRUG METABOLISM. Metabolic pathways Metabolizing enzymes & transporters

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MLAB 2401: Clinical Chemistry Keri Brophy-Martinez

MLAB 2401: Clinical Chemistry Keri Brophy-Martinez. Alterations in Liver Function. Jaundice/Icterus. Yellow discoloration of the skin, eyes and mucous membranes Due to the presence of bilirubin Onset seen at bilirubin levels > 3.0 mg/dL Kernicterus

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CHAPTER 12

CHAPTER 12. Sedative-Hypnotic Drugs and Alcohol. Sedatives and Hypnotics. Sedatives are drugs used to induce a mild state of CNS depression characterized by both mental and physical calmness Hypnotics are drugs used to induce and maintain sleep

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Pharmacokinetics (PK): What the body does to the drug?

Pharmacokinetics (PK): What the body does to the drug?. Most drugs: Enter the body by crossing barriers Distributed by the blood to the site of action Biotransform perhaps to several different compounds by enzymes evolved to cope with natural materials Excreted

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Lesson on Plant Cells

Lesson on Plant Cells. Plant Cell. Nucleus Cytoplasm Endoplasmic Reticulum (ER) Golgi Apparatus Lysosomes Mitochondrion Ribosomes Cell Membrane Cell Wall Chloroplast Vacuole. Nucleus.

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Metabolism of Xenobiotics

ENVR/TOXC 442 Fall 2012. Metabolism of Xenobiotics. I. General Overview Aug 21, 2012 L.M. Ball Rosenau 158 lmball@unc.edu. Metabolism : Chemical reactions carried out by and in living systems Breakdown of organic matter (eg food) to release energy ( catabolism )

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Metabolism of Xenobiotics

ENVR/TOXC 442 Fall 2012. Metabolism of Xenobiotics. I. General Overview Aug 21, 2012 L.M. Ball Rosenau 158 lmball@unc.edu. Metabolism : Chemical reactions carried out by and in living systems Breakdown of organic matter (eg food) to release energy ( catabolism )

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The Urinary System & Excretion

The Urinary System & Excretion. Detoxification of the Blood. The Urinary System. Remember!. The liver detoxifies the blood by removing poisonous substances and detoxifying them. the Deamination of amino acids produces ammonia, a poison, which is then converted to urea.

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