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PET – POSITRON EMISSION TOMOGRAPHY

Explore Positron Emission Tomography (PET) principles, radiotracers, and applications in diagnosing tumors. Learn about PET-CT images and its significance in oncology.

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PET – POSITRON EMISSION TOMOGRAPHY

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  1. PET –POSITRON EMISSION TOMOGRAPHY

  2. PET: POSITRON EMISSION TOMOGRAPHY

  3. Most used PET radiotracers

  4. Unstable nucleus positron antiparticle of the electron (same charge, opposite semn) electron positronium 2 gamma photons, 511 keV Coincidence detection (interval 10-9 sec.) • detector: • Bi germanat crystal(BGO) • Photomultipliers around PET principle

  5. Anihilation process Anihilation photon g Anihilation electron/positron b- b+ Anihilation photon g Desintegration through positron emission Device

  6. PET: analogs metabolic Glucidic Metabolism Glicolisys in malignant cell The germinating idea of PET: Nobel Prize Medicine Laureat, Dr. Otto Warburg: <The prime cause of cancer is the replacement of the respiration of oxygen by normal body cells by a fermentation of sugar>

  7. GLUT transporters GLUT8 GLUT6

  8. 18FFDG (18F-2fluoro-2deoxi-Dglucose)

  9. PET Indication • Miocardial Scintigraphy • Tumoral Scintigraphy : • pulmonar neoplasm • mamary neoplasm • cerebral neoplasm • ovarian • gastrointestinal neoplasia • limphoma • Head-neck tumors • endocrin tumors : thyroidian, carcinoid, pheocromocitoma

  10. Normal 18FFDG PET image

  11. Normal PET and PET-CT images

  12. Pathologic 18F FDG PET images in cancer

  13. Lung cancer

  14. Lung cancer with metastases

  15. Hodgkin lymphoma with metastases

  16. Melanoma

  17. PET-CT images

  18. Imagini PET (18FFDG), CT şi PET-CT normale (secţiuni coronale) PET PET - CT CT

  19. PET + CT = PET-CT

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