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Explore the synergistic effects of CBP and PCAF bromodomain proteins in regulating gene expression and enhancing cellular functions. Learn about their roles in transcriptional activation and potential therapeutic applications.
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IB: CBP_BRD (a-CBP_BRD) IB: PCAF_BRD (a-PCAF_BRD) IB: PCAF (a-PCAF_BRD) IB: PCAF (a-FLAG) IB: CBP (a-HA) IB: b-Actin (a-b-Actin) pCMV Vector pHIV-LTR-Luc Tat CBP PCAF PCAF_BRD CBP_BRD +- - - - - - ++- - - - - +++ - - - - ++- + - - - +++ + - - - ++- - + - - +++ - + - - +++ + + - - +++ + + + - +++ + + - + 0 1 2 3 4 5 6 7 8 9