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  1. Animation • http://highered.mcgraw-hill.com/olc/dl/120077/micro06.swf Home: • http://highered.mcgraw-hill.com/sites/dl/free/0072437316/120060/ravenanimation.html

  2. Figure 17.0 Ribosome

  3. The triplet code

  4. Overview: the roles of transcription and translation in the flow of genetic information (Layer 5)

  5. The 20 amino acids of proteins: nonpolar

  6. The dictionary of the genetic code

  7. A tobacco plant expressing a firefly gene

  8. The stages of transcription: elongation

  9. The initiation of transcription at a eukaryotic promoter

  10. The stages of transcription: elongation

  11. Figure 17.8 RNA processing; addition of the 5 cap and poly(A) tail

  12. Figure 17.9 RNA processing: RNA splicing

  13. The roles of snRNPs and spliceosomes in mRNA splicing (& Ribozymes)

  14. Sliceosomes • http://highered.mcgraw-hill.com/olc/dl/120077/bio30.swf

  15. Figure 17.11 Correspondence between exons and protein domains

  16. Overview: the roles of transcription and translation in the flow of genetic information (Layer 5)

  17. The nucleus and its envelope 

  18. Translation: the basic concept

  19. Codon/A.A. dictionary

  20. The structure of transfer RNA (tRNA)

  21. The structure of transfer RNA (tRNA)

  22. Aminoacyl-tRNA synthetase: joins amino acid & tRNA

  23. The anatomy of a functioning ribosome

  24. Ribosome and Protein Production • Steps: • 1) Initiation2) Elongation3) Termination • Each step requires • Protein Factors

  25. Initiationof translation

  26. Elongation of translation

  27. Termination of translation

  28. Video of Ribosome& polypeptide synthesis • http://highered.mcgraw-hill.com/olc/dl/120077/micro06.swf

  29. Polyribosomes:Quick & Massive Protein Production

  30. Video protein synthesis in Prokaryote & Eukaryotes http://highered.mcgraw-hill.com/olc/dl/120077/bio25.swf (Optional in class)

  31. Review: the four levels of protein structure

  32. A chaperonin in action

  33. The signal mechanism for targeting proteins to the ER

  34. The nucleus and its envelope 

  35. Ribosomes

  36. Endoplasmic reticulum (ER)

  37. The Golgi apparatus

  38. Types of RNA in a Eukaryotic Cell

  39. Coupled transcription and translation in bacteria

  40. The dictionary of the genetic code

  41. Figure 17.23 The molecular basis of sickle-cell disease: a point mutation

  42. Base-pair substitution

  43. Base-pair insertion or deletion= FRAMESHIFT

  44. A summary of transcription and translation in a eukaryotic cell

  45. End: Protein Synthesis

  46. Nuclei and F-actin in BPAEC cells

  47. Last female WWI vet dies at 109 Typical female yeoman uniform, however, this is not Mrs. Winters. Charlotte Winters (Nov 10,1897- Mar 27, 2007) Boonsboro, Maryland

  48. Last Navy vet of WWI dies at 105 Lloyd Brown (October 7 1901- March 29, 2007) Charlotte Hall, MD