The Enteric Nervous System in Chagasic and Idiopathic Megacolon. Guido Iantorno, MD,* Gabrio Bassotti, MD, PhD, w Zulema Kogan, MD, z Carlos Miguel Lumi, MD, y Ana Maria Cabanne, MD, z Simona Fisogni, MD,J Liliana Monastra Varrica, MD,* Claudio R. Bilder, MD,* Juan Pablo Munˇoz, MD, y
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Guido Iantorno, MD,* Gabrio Bassotti, MD, PhD, w Zulema Kogan, MD, z Carlos Miguel Lumi, MD, y Ana Maria Cabanne, MD, z Simona Fisogni, MD,J
Liliana Monastra Varrica, MD,* Claudio R. Bilder, MD,* Juan Pablo Munˇoz, MD, y
Barbara Liserre, MD,J Antonio Morelli, MD, w and Vincenzo Villanacci, MDJ
(Am J Surg Pathol 2007;31:460–468)
(C), compared to that of a chagasic patient controls and patients with idiopathic megacolon (Fig. 1C)
(D), showing no enteric neurons (hematoxylin and eosin,
original magnifications: C, 20; D, 40).
(C) and in a chagasic patient concerning these markers.
(D) showing an increase in the latter (A-D: CD 117, original magnification 40).
Presence of mast cells
(arrow) in the circular colon
musculature of a patient with
Chagas disease (CD117
, original magnification 40).
Apoptotic neurons (arrows) in
the colonic submucosal plexus
of a idiopathic megacolon patient
(formamide-Ab, original magnification 100).
Presence of lymphocytes (arrows) within a colonic (8 to 15) than in idiopathic megacolon, and were found in the submucosal (2 cases) and the myenteric (4 cases) plexus
of a chagasic patient (CD3: C, original magnification 40; D, 100).
Thanks for present in patients with chagasic and idiopathic megacolon.