1 / 13

Emmanuel Lollis Eunji Youn Jaehoon Jeong Jordan Angie

Materials that Expand, Swell, or Change Shapes in the Stomach CE 404 Product Design Project 3: Request for Proposal. Emmanuel Lollis Eunji Youn Jaehoon Jeong Jordan Angie. Physical and Chemical Forces Imposed by the Human Body. Pressure Potential mastication Gastric motility Enzymes

rhona
Download Presentation

Emmanuel Lollis Eunji Youn Jaehoon Jeong Jordan Angie

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Materials that Expand, Swell, or Change Shapes in the StomachCE 404 Product Design Project 3: Request for Proposal Emmanuel Lollis EunjiYoun JaehoonJeong Jordan Angie

  2. Physical and Chemical Forces Imposed by the Human Body • Pressure • Potential mastication • Gastric motility • Enzymes • Salivary amylase (breaks down starch) • Lysozyme (breaks down bacterial cell walls) • Pepsin (denatures proteins) • Gastric lipase (breaks down fats) • Solvents • Gastric acid (pH of 2) • Mucus infused with bicarbonate (pH of 7)

  3. Specifications • The request for proposal outlined some specifications

  4. Customer Needs

  5. High-level Concepts: Gas-generating devices • Digestible capsule breaks down • Barrier breaks • Gas-forming reaction commences • Drug-infused degradable porous polymer matrix delivers drug over time • Once the porous polymer matrix fully degrades, a hole is exposed through which gas can pass, allowing the device to deflate How it would work Limitations • Device will prematurely expand if crushed

  6. High-level Concepts: Shape-Memory Polymer Technology • Digestible capsule breaks down • Strands of shape-memory polymer material straighten out when exposed to low pH • Drug-infused degradable porous polymer matrix delivers drug over time, decreasing in size until it is gone • Buckyball-like structure physically breaks apart due to gastric contractions How it would work Limitations • Device may prematurely break down if covered by neutral mucus in the stomach • Consumer cannot drink any basic drinks while the pill is dispensing drug • The device might cause discomfort when passing through the pyloric sphincter

  7. High-level Concepts: Electronic Capsule • Digestible capsule breaks down • pH sensor triggers the inflation of the biocompatible balloon • Drug-delivery door opens and closes at pre-programed intervals • Device deflates the biocompatible balloon after delivering the entire payload How it would work Limitations • The inner workings of the electronic capsule are intricate (motor, pump, sensor, processor), which would make it difficult to manufacture

  8. High-level Concepts: Hydrogel • Digestible capsule breaks down • Hydrogel absorbs water in the stomach and quickly expands • Drug-infused degradable porous polymer matrix is exposed to water in the hydrogel. It breaks down, and drug diffuses through the hydrogel. • Hydrogel eventually breaks down into fragments that get smaller and smaller How it would work Limitations • Common hydrogels are not strong enough to withstand the forces imposed by gastric motility

  9. Concept Selection

  10. Final Design Biodegradable controlled release porous polymer matrix surrounded by a superporous hydrogel composite material, all enclosed in a digestible gelatin capsule. Figure (above) - Degradable controlled release porous polymer matrix. Figure (left) – Superporous hydrogel composite material

  11. Processing and Manufacturing • Main Equipment needed • Milling and micronizing equipment • Reaction vessel or mixing tank with stirrer • Moisture chamber for encapsulation • Synthesis of Super-porous Hydrogel • Scale up laboratory synthesis method • Sequential addition of mixture resulting in gelation of cross-linked SPH • Acidification: gastric fluid is used to wash hydrogel for 24 hours • Dry SPH for 5 days • Formulation of degradable porous polymer matrix (PLGA synthesis) • Racial polymerization of lactic acid and glycolic acid • Prepare micro-particles of PLGA using emulsion technique and drug of choice is inserted • Mold matrix into small oval/ circular shape while it is still in an amorphous state

  12. Processing and Manufacturing • Formulation of degradable porous polymer matrix (PLGA synthesis) • Racial polymerization of lactic acid and glycolic acid • Prepare micro-particles of PLGA using emulsion technique and drug of choice is inserted • Mold matrix into small oval/circular shape while it is still in an amorphous state • Inserting hydrogel into hard gelatin capsule • Moisture the dried hydrogel and soften it in moisten chamber • Encapsulation: squeeze softened hydrogel into small gelatin capsule • Quality Control Check • Ensure proper functioning of the drug • Check quality during the process in line and after manufacture

  13. References • Chen, Jun, William E. Belvins, Haesun Park, and Kinam Park. "Gastric Retention Properties of Superporous Hydrogel Composites." Journal of Controlled Release 64.1-3 (1998): 39-51. Web of Science. Web. 10 Nov. 2013. • Rothstein, Sam N., and Steven R. Little. "A “tool Box” for Rational Design of Degradable Controlled Release Formulations." Journal of Materials Chemistry (2011): 21-29. Web of Science. Web. 16 Nov. 2013. • "Biomaterials and Bioanalogous Polymer Systems." Biomaterials and Bioanalogous Polymer Systems. Institute of Macromolecular Chemistry of the Academy of Sciences, n.d. Web. 16 Nov. 2013.

More Related