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ANTACIDS. Human Stomach. Gastric juices in stomach Contain HCl ( aq ) Ph 1-3 To suppress growth of bacteria To help in digestion by hydrolysing proteins to amino acids. Indigestion. Excess acid production Abdominal discomfort after eating Over eating Stress Certain foods

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Human stomach
Human Stomach

Gastricjuices in stomach

ContainHCl (aq)

Ph 1-3

Tosuppressgrowth of bacteria

Tohelp in digestionbyhydrolysingproteinsto amino acids


Indigestion
Indigestion

Excessacidproduction

Abdominal discomfortaftereating

Overeating

Stress

Certainfoods

Acideatsawayprotective mucus layer

Painfululcers


Antacids1
Antacids

Remedyforexcessstomachacidity

Bases

Metal oxides, hydroxides

Metal carbonates

Metal hydrogencarbonates

(bicarbonates)


Effect of antacids
Effect of Antacids

Neutraliseexcessacid and adjuststomachphtodesiredlevel

Stomachliningrepairsitself

Active ingredients

Aluminiumhydroxide

Magnesiumhydroxide

Sodiumhydrogen carbonate


Alginates
Alginates

Combinedwithantacids

Extractedfrombrownseaweeds

Produce a neutralisinglayerrthatpreventsacidreflux

E.g. theypreventacidfromrisingintooesophagus

«Heartburn»


Dimethicone
Dimethicone

Anti-foamingagent

Addedto reduce surfacetension of gas bubbles

Causes bubblestocoalesce (come together)

Produces defoamingaction


Side effects
Sideeffects

Aluminiumhydroxidemay cause constipation

Can preventuptake of phosphateions (precipitation of aluminiumphosphate)

Largechargetosizedensity leads tobindingwithotherdrugs


Side effects1
SideEffects

Magnesiumhydroxide has laxativeproperties

Calcium carbonate may lead tokidneystones

Sodiumionsmay lead tohypertension


Alkalosis
Alkalosis

Takingtoomuchantacid leads toalkalosis (a rise in ph of blood)

Also can lead toexcessiveamounts of calciumions in body


Question
Question

Twosolidantacidproductscontainsamemass of different active ingredients. Onecontainssodiumbicarbonate, theothercalcium carbonate. Whichisthebetterbuy and why ?


To do
To Do

Look at active ingredients of antacidson page 410

Also look at chemicalequations

Then try question 3 on page 434