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Antacids

Antacids. Acid Base Chemistry. http://redpoll.pharmacy.ualberta.ca/drugbank/  Description: The DrugBank database is a unique bioinformatics and cheminformatics. http://www.rxlist.com/script/main/hp.asp . Antacids. 12.2 Antacids.

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Antacids

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  1. Antacids Acid Base Chemistry

  2. http://redpoll.pharmacy.ualberta.ca/drugbank/ Description:The DrugBank database is a unique bioinformatics and cheminformatics

  3. http://www.rxlist.com/script/main/hp.asp 

  4. Antacids

  5. 12.2 Antacids • State and Explain how excess acidity in the stomach can be reduced by the use of different bases. • Antacids: bases, metal oxides, hydroxides, carbonates, hydrogen carbonates • Reacts with stomach acid (excess) to adjust the stomach pH to the desired level

  6. Purpose of HCl in the stomach • To suppress growth of harmful bacteria • To help in digestion by hydrolyzing proteins to amino acids • Normal pH of stomach acid ~ • 1.2 – 0.3 range, • Stress also produces more acid

  7. Role of antacids • Neutralizes the excess acids and relives the discomfort • Excess acid can cause ulcers

  8. Examples: Over the Counter • Al(OH)3 Mg(OH)2 CaCO3 • NaHCO3

  9. Alginates • Antacids are combined with Alginates • extracted from brown sea weeds • produces neutralizing layer that prevents acid reflux / acid entering into oesophagus

  10. Dimethicone / Antifoaming agent • Are added to antacids to reduce the surface tension of gas bubbles • And produce de-foaming action

  11. Silicon Chemistry • The possibilities offered to the formulation chemist by silicone chemistry are endless and yours to explore.

  12. Active ingredients of some commercial antacids • Tums: CaCO3 MgCO3 Mg Si3O8 • For the treatment of gastritis and of ulcers • Rolaids : AlNa(OH)2CO3 • Malox : Al(OH)3 Mg(OH)2 • Alka Seltzer : NaHCO3 , citric acid, aspirin

  13. Alka Seltzer : NaHCO3 , citric acid, aspirin

  14. Active ingredients of some commercial antacids • Milk of Magnesia : Mg(OH)2 or MgO/Mg(OH)2 mixture • Amphogel Al(OH)3 • Di-Gel : CaCO3

  15. Action of Antacids • Mg2Si3O8 + 4 HCl 3 SiO2(s) • 2 H2O (l) + 2 MgCl2(aq) • Write the reactions for rest of the antacids • Alkalosis: high doses of antacids • basic stomach • Other problems: body produces more acids

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