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Biol 302 Spring 2011 Quiz: Gene Structure and Drosophila Segment Identity

This quiz assesses understanding of gene structure, splicing differences, protein-DNA interactions, and Drosophila segment identity. Students are required to draw and label a complete gene, differentiate splicing and recombination, and analyze the effects of amino acid substitutions in homeodomain proteins. Additionally, students will interpret segment identities in Drosophila patterns based on various genetic manipulations. Each question has specified point values based on accuracy and completeness of the responses.

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Biol 302 Spring 2011 Quiz: Gene Structure and Drosophila Segment Identity

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  1. 20pts total Quiz 3: Biol 302 Spring2011 Name:_______________ Question 1: Draw and Label a Two Exon Complete Gene. 10pts-labeling 14 structures correctly, 8pts-labeling 10-13 structures correctly, 5pts-labeling 6-9 structures correctly. 0pts for less than 6 structures labeled correctly or for any inaccuracies. 5’ 3’ Question 2: The two differences between splicing of a transcript and gene recombination are: 1pt_______________________________ 1pt_______________________________ Question 3: Given the following DNA binding motif: Helix2-turn-Helix3 for a homeodomain protein. Trp48, Phe49, Asn 51 and Arg53 are invariant amongst almost all homeodomains in order to retain DNA binding. However, you want to test this idea with single amino acid substitutions. (2pts for 3 correct) What will you change Trp48 to: _____ What will you change Phe49 to: _____ What will you change Asn51 to: _____ What will you change Arg53 to: _____

  2. T2 T2 Question 4: :Given the following patterns produced in Drosophila segments starting from #1(WT) Fill in appropriate segment identity in boxes below. WT #1 plus overexpression of Antp in all segments, 2pts #1 plus overexpression of Ubx in all segments, 2pts #1 plus overexpression of AbdA in all segments, 2pts #1 minusUbx #1 Minus Antp #1 Antp - Antp GS Ubx Ubx Antp A1 A1 T2 AbdA AbdA AbdA A2 A2 A2 AbdA AbdA AbdA A2 A2 A2 AbdA AbdA AbdA A2 A2 A2 AbdA AbdA AbdA A2 A2 A2 AbdA AbdA AbdA A2 A2 A2 AbdA AbdA AbdA A2 A2 A2 Extra Credit 2pts: The above results of segment identity can be explained in two ways Either the _____________________________________________________ or ________________________________________________________________________

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