NIDCD Grantees Investigating Long Term Outcomes of EHDI Programs. Amy M. Donahue, Ph.D. NIDCD. Faculty Disclosure Information.
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Amy M. Donahue, Ph.D.
Faculty Disclosure Information Programs
In the past 12 months, I have not had a significant financial interest or other relationship with the manufacturer(s) of the product(s) or provider(s) of the service(s) that will be discussed in my presentation
This presentation will (not) include discussion of pharmaceuticals or devices that have not been approved by the FDA or if you will be discussing unapproved or "off-label" uses of pharmaceuticals or devices.
National Institute on Deafness and Other Communication Disorders (NIDCD)
and EHDI Research
2006 National Early Hearing Detection and Intervention Conference
Amy Donahue, Ph.D.
Much of the biomedical research in the United States Disorders (NIDCD)is supported by the Federal Government, primarily the National Institutes of Health (NIH)
FY2000 2001 2002 2003 2004 2005 2006
NIH budget doubling
$(M) 264 300 341 370 382 394 397
% 15.0 14.0 13.6 8.4 3.2 3.2 -0.5
R01 40 43 41 42 36 27 ?
Hearing 51 %
Mechanism Reviewed Awarded Rate (%)
R01 514 141 27.4
R03 (Small) 95 29 30.5
R15 (AREA) 18 6 33.3
R21 (Exp/dev) 121 19 15.7
New Inv R01 88 24 27.3
Approx 40,000 infants year born with CMV
10- 15% will develop HL, many will have delayed onset
7-year study to evaluate presence of CMV and long-term audiologic/otologic outcome and address validity and utility of CMV screening in the detection of HI in the newborn period and prediction of late-onset HL after newborn period
University of Alabama, Birmingham
Seven sites- MS, NC, NJ, PA, OH, TX, AL
“Whole” Child: cognitive, social and behavioral development.
Systematically evaluating the predictive value of variables as they relate to outcomes of oral language acquisition, speech recognition skills, selective attention and problem-solving skills, behavioral and social development, parent-child interactions, and quality-of-life measures in children implanted in six U.S. implant centers.
Data will contribute to understanding of the factors predicting implant-associated language use, communication competence in early childhood, psychosocial development, and the perceived value of early cochlear implantation in light of associated costs.
Conclusions will enable a refined approach to implant candidacy when considering (re)habilitative strategies designed to optimize the development of children with severe-to-profound SNHL.
Clinical outcomes research in 20th year.
studying the selection criteria for implantation;
developing a reliable evaluation strategy including accurate assessment of auditory thresholds;
developing signal processing for speech perception and music appreciation;
assessing communication outcomes (speech production, language, reading, writing, and music appreciation) of children using hearing aids and/or implants; and
determining the factors that affect the long term benefit of cochlear implants in adults and children.
Goal is to gain an understanding of the early word-learning processes of children with hearing loss, and to delineate factors that influence language development.
Many hard-of-hearing (HH) children are slower than normal-hearing (NH) children to develop similar lexicons, even with early intervention. Sources of early delays and individual differences in long-term outcomes in this population are not well understood.
Is early lexical development influenced by complex interactions of maternal, child, and environmental factors.? This study systematically examines the factors that influence word learning in HH infants.
Characterize the rate and course of word learning in HH children in the context of mother-child interaction, providing baseline data on word learning in HH children, as well as guidelines for measuring progress and adjusting interventions in clinical settings.
Word-learning experiments and parent surveys are conducted to determine if HH children are able to learn words from incidental exposure. Explore the role of children's social understanding in vocabulary development, and determine how conversations about thoughts and feelings influence children's knowledge.
Outcome to provide direction for early interventionists in their efforts to promote nurturing caregiver-child interactions.
There are few clinical measures to assess speech perception abilities in infants as they mature. Better measures are needed for decision-making regarding early intervention. This study focuses on auditory-perceptual development and the emergence of spoken language in the young hearing-impaired child.
Goal: develop and refine new behavioral assessment tools to measure speech perception in children between the ages of 6 months and 5 years. Longitudinal and cross-sectional studies.
1) ascertain the extent to which assessment task contributes to variability on measures of speech perception,
2) measure changes in performance over time as a function of chronological age, assessment task, auditory status, and sensory assistance;
3) investigate the relationship between speech recognition and linguistic / cognitive variables in young developing children with hearing loss;
4) to describe and measure the contributions of maternal involvement to performance on tasks of language and speech perception in hearing-impaired young children, and to validate parent report as a tool for assessing language development.
Annual distribution through the NIDCD Information Clearinghouse:
2010 target: 70%
Dr. Amy Donahue or Dr. Lynn Luethke
Chief, Office of Health Communication and
Public Liaison, NIDCD