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Executive Summary

Executive Summary. Platform Technology (TSCP): Fusion proteins with two functional ends First-in-class drugs to convert inter-cellular signals Studied for a decade / Multiple scientific publications Wide IP estate licensed from the University of Pennsylvania Products

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Executive Summary

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  1. Executive Summary • Platform Technology (TSCP): • Fusion proteins with two functional ends • First-in-class drugs to convert inter-cellular signals • Studied for a decade / Multiple scientific publications • Wide IP estate licensed from the University of Pennsylvania • Products • Pipeline: Four TSCP fusion combinations • Two products in pre-clinical development • Autoimmune indications with unmet needs • KAHR-101 • Complete production process developed • Efficacy demonstrated in multiple animal disease models • Clinical trials expected in 2010 in RA patients

  2. Company Information • Hadasit Bio-Holdings (“HBL”, TASE: HDST) portfolio company • Located in Israel • Operations initiated mid 2007 • Platform technology; ‘Trans signal converter proteins (TSCP)’. Licensed from the University of Pennsylvania • Leading products: KAHR-101 & KAHR-102 for the treatment of autoimmune diseases

  3. Team • CEO – Dr. Noam Shani, Ph.D. Previous VP-R&D for Medgenics (AIM: MEDG) and for Compugen (NASDAQ: CGEN) • Research Officer- Dr. Michal Dranitzki Elhalel, M.D. Senior physician and scientist at the Hadassah Medical Center. Investigating the TSCP technology since 2000 • Scientific Advisory Board • Prof. Marc Feldmann, M.D., Ph.D. Head, Kennedy Institute of Rheumatology - Imperial College, London. Developed Ramicade (J&J) • Prof. Lawrence Steinman, M.D. Chair of Immunology at Stanford University. Developed Tysabri (Biogen-Idec) • Dr. Nabil Hanna, Ph.D. Previous Executive Vice President Research, Biogen-Idec. Developed Rituximab and Zevalin (Biogen-Idec) • Prof. Mark Tykocinski, M.D. Dean, Jefferson Medical College, Philadelphia. Inventor of the TSCP platform technology

  4. Platform Technology: TSCP • Represents the third generation of protein-based therapeutics • First generation: Protein with one functional unit and one target (e.g. IFN, EPO, hGH) • Second generation: Protein with twofunctional units and one target (e.g. mAb, Fc-fusions) • Third generation: Protein with twofunctional units and two targets (TSCP molecules) • Fusion proteins with Two functional ends • Both sides transmit different and complementary intercellular or intracellular signals • Intensely studied for a decade, mostly by U. Penn and Hadassah teams • Drug potential documented in multiple scientific publications * • IP was licensed from U. Penn * See website for scientific publications – www.kahr-medical.com

  5. KAHR-101/102 Three-Year Plan

  6. KAHR Opportunity • Technological breakthrough – TSCP platform technology • Huge market with unmet clinical needs • Competitive advantage over existing paradigm • Robust development pipeline • Strong IP portfolio • Seasoned team • KAHR has initiated a series-A financing round and is seeking strategic investments, licensing and co-development collaborations

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