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Breakthrough in Genomic Discovery: Unveiling Disease Risk Factors

Dive into the pioneering Genome-wide Association Studies (GWAS) conducted by the Wellcome Trust Case Control Consortium. This landmark research involved a genome-wide scan for seven diseases, identifying 24 genetic risk factors across 58 loci. Explore the study's findings on association signals with p-values indicating significant correlations, particularly in diseases like coronary artery disease and myocardial infarction. Witness the replication and validation of these genetic associations, shedding light on the complex genetic underpinnings of human diseases. Join the journey of discovery as guilt-by-association becomes a powerful tool for understanding disease susceptibility.

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Breakthrough in Genomic Discovery: Unveiling Disease Risk Factors

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  1. A new dawn Genomewide association studies (GWAS)

  2. Genome-wide scan for seven diseases P<1x10-5 Green WTCCC, Nature 7 June 2007

  3. Genome-wide association scan • 2,000 individuals for each of the 7 major diseases • 3000 shared controls • 24 independent association signals identified at p<5x10-7 • Across all diseases-58 loci • (6 for HT) with p values between 10-5and 5 x10-7

  4. Association of SNPs with coronary artery disease or myocardial infarction Cyclin dependent kinase inhibitors 2A & 2B Replication Samani et al, NEJM 2007;357:443

  5. Guilt by association- WTCCC In a tour-de-force demonstration of feasibility, a consortium of 50 research teams used 500,000 genetic markers from each of 17,000 individuals to identify 24 genetic risk factors for 7 common human diseases Nature, 7 June 2007 Wellcome Trust Case Control Consortium

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