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How many patients does case series should have In comparison to reports - Pubrica

Case reports are defined as the scientific documentation of a single clinical observation and have a time-honored and rich tradition in medicine and scientific publication. Pubrica has extensive experience in developing a detailed clinical case report that highlights the symptoms, signs, diagnosis, treatment and follow-up of an individual patient.<br>Continue Reading: https://bit.ly/34RO9vU<br>For our services: https://pubrica.com/services/research-services/case-report-writing/<br>

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How many patients does case series should have In comparison to reports - Pubrica

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  1. HOWMANYPATIENTS DOES CASE SERIES SHOULDHAVE INCOMPARISONTO CASEREPORTS AnAcademicpresentationby Dr.NancyAgnes,Head,TechnicalOperations,Pubrica Group: www.pubrica.com Email:sales@pubrica.com

  2. Today'sDiscussion Outline In-Brief Introduction WhentoConsideraCaseSeries WhenHighAcceptanceRateisPossible SubjectsinCaseSeriesandCaseReport MeritsandDemerits Criteria Conclusion

  3. In-Brief The medical research field is continuously expanding, with more amount of data, being generated every day. In clinical research, several studies have been classified into descriptive and analytic studies. Descriptive studies include cross- sectionalstudies,ecologicalcorrelationalstudies,casereportswriting,caseseries report writingand surveillance studies. On the other hand, analytical studies examineahypothesisaboutacausalrelationshipbetweenexposureand outcome. Since the objective of this article is on case report and case series, the analyseswouldbe restrictedonly tothose typeof studiesalone.

  4. Introduction A case series and case reports consist of either of aggregate of individual cases in one publication on the diagnosis and treatment or a report of a single patient. A high number of case reports been received for publication, but it seems the rejection rate of CRs is quitehighacross manyjournals. Thisisbecause,accordingtotheprincipleof evidence-basedmedicine,theyprovidealower strengthofevidenceamongclinicalstudies,as shownin Figure1. Contd...

  5. Outoftwodifferentformsofclinicalresearchstudies –(i)descriptiveand(ii)analytic,caseseries(CS) andcasereports(CR)fallunderdescriptiveone. Inspecific,casereports/seriesareusually retrospective and occasionally be prospective, such astheHerrick’sfirstcasereportofsicklecell disease. Contd...

  6. When to Consider a CaseSeries If you intend to publish your case reports and case series,rememberyourreportsshouldbethefirst document medical breakthroughs i.e., reporting of rare diseases in identifying adverse or beneficial outcomes of interventionornoveldiagnosticortherapeuticstrategies. Further,theprimarypurposewastogenerate hypotheses that can be subsequently tested in studies of greatermethodological rigour. Contd...

  7. Therefore,caseseriescanbeappliedtoassessthetreatmentsafetyand diagnostic accuracy, and in fact, no control group is necessary with good long-term follow-up. In order to get your research to be funded, there is a need for preliminary evidence onwhich tobase thebelief thata treatmentmay beefficacious. Inthiscase,thesereportsoftenprovidethefirstlevelofevidence. AstudypublishedintheJournalofClinicalEpidemiologyexaminedthecase reportsand caseseries published inThe LancetJournal. Contd...

  8. The study demonstrated that case series that are carefully designed and, of course, similar to clinical trials are likely to minimize bias and maximize the informationthatcan bededuced fromalimited numberof patients. Besides, in order to publish your reports, need to ensure that both case series and reports have to follow a standard structure and methodological rigour with referencetoselection, ascertainment,casualty andreporting. The following section highlights the difference between these two reports and possibleways toget itpublished in Highimpact journals.

  9. When High Acceptance Rate is Possible Differencebetweenacaseseriesandacasereport Acaseseriesingeneralcarriesinformationacquired from various sources containing one or more information about the disease, treatment, diagnostic methods, etc., whereas a case report contains a very less amount of dataandmaycontainin-depthdemographicaldetails. It takes more time to accept the case series than the timetakentoacceptthecasereportbyanypublisher. Contd...

  10. Case reportsare professional narratives that offer feedback on clinical practice guidelinesandprovidesaframeworkforadverseevents,initialsignalsof effectiveness,and cost. Theycanbesharedformedical,scientific,oreducationalpurposes.

  11. Subjects in CaseSeries and Case Report Many publishers strongly stick to the count of the patientsreported inthe study. After the study reports, [1] suggested that a case report contain patients of less than five individuals, whereas a caseseriescancontainfourandmorepatients. Few journals have no upper limit set for the case series; otherjournalsacceptnearly20patientsreportasa singlecase series. Contd...

  12. Meritsand Demerits Both case series and case report writinghave their meritsand demerits. Case series is very useful in rare case scenarios where anewkindofdiseaseordisorderharmsthesubject. Also,thepublishersmaymakefewnegotiationsin considering a case series due to the biased contents basedupontheeditors' personalopinions. Besides,caseserieshashighexternalvalidity,no interference in treatment decision process, wide range ofpatientsand finallyinexpensive. Contd...

  13. Intermsoflimitations,thestudylackofcomparison groups, data collection often be incomplete, susceptible tobias,selectionand measurementbias. Ontheotherhand,casereportshelphealthcare professionals easily understand the cases and take less timeto be prepared. But case reports may not possess all the relevant and minutedetailsto treatthe subjects. Norandomisationisfollowedinacaseseries; therefore,itbecomesmoreefficientandaffordable.

  14. Criteria • Whenever a case series is getting developed, few criterianeed tobe followed. • Title–Remembertoincludethewords“caseseries”and thearea offocus in thetitle • Abstract’–Introduction-Unifyingthemeofthecase seriesshouldbe emphasized • Methods–whatwasdone,howandwhen. • Results–whatwasfound. • Conclusion–whatwehavelearned. • Contd...

  15. Introduction–emphasizethescientificbackground andrationale. Design –the research registry number (ResearchRegistry.comorClinicalTrials.govor ISRCTN), list the intended population, process manner,andend outcome. Theremustbeapropermethodtoacquirethedata like regular telephone calls, clinical observation, and more. Study design should be sated including prospective, retrospectivein design. Contd...

  16. Also, enough time should be given between continuous follow-ups. Not a case series would be attractive when taking the subjectcasesthatlastmorethanayearbecause increasing the period may lead to disruption of study in the middle due to any unexpected situations like the patientwoulddieorrelocatehis/herplaceorchange thehospital. (ii) Analysis – Descriptive statistics and methodologies mustbeusedwhileanalysingandnocomparativetests yieldingpvalues shouldbecarried out. Contd...

  17. (iii) Reporting – A case series must report the subject detailsandprogress,completedetails,andanalyse everyfollow-up. Theremustbenodeclaredconclusionsattheend because once a valid conclusion is declared, it makes theinvestigatorskeeponupdatingtheresultsby comparingwithotherresults,whichdevelopsaneed forhypothesis testing. Contd...

  18. The researcher must understand the limitations before gettingengagedandpossessawarenessaboutthe conclusions. Pubricahasextensiveexperienceindevelopinga detailed clinical case report Writing Servicesthat assist inhighlighting thescientific documentation. Contd...

  19. Conclusion Bothcaseseriesandcasereportsintheclinical research field are meant to be utilized by healthcare professionals. Except for the distinguishing features between a case series and a case report, they both tend to give valid informationwithtimely intervention. Contd...

  20. If both are well prepared from the initial stages, they can even be alternatives to another level of studies employedmoreconfidentlythantheformer. Reportingcaseseriesinastandardizedand statistically appropriate manner would allow for proper interpretation at the same time enable to conduct of futuremeta-analysestoproduceestimatesforthe long-termoutcomes.

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