DNA:chromatin interactions. Exploring transcription factor binding and the epigenomic landscape Lisa Stubbs. Eukaryotic genomes are complex structures comprised of modified and unmodified DNA, RNA and many types of interacting proteins.
Exploring transcription factor binding and the epigenomic landscape
All four histones in the tetramer have “tails” that can be modified in various ways, but the most consequential modifications, with respect to transcriptional activity, appear to involve methylation or acetylation of Lysines (K) in histone H3
The first approach: from Crawford et al., Genome Research 16:123, 2006 (Francis Collins’ laboratory)