The Myc Transcription Factor. By: Michael Reisfeld. MYC Was Originally cloned From a transforming Virus . Myc is a Transcription Factor Which Dimerizes With a Leucine Zipper and binds to DNA Via a Helix-Loop-Helix. Myc is part of pathway that promotes Cell Proliferation.
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By: Michael Reisfeld
Burkitt’s Lymphoma (c-myc)
Small Cell Lung Cancer (L-myc)
Bellan, C et al. “Burkitt’s lymphoma: new insights into molecular pathogenesis.” Journal of Clinical Pathology. 11 July 2002; 56:3, 188-192.
CollerHA, Grandori C, Tamayo P, Colbert T, Lander ES, Eisenman RN, et al. ”Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion.” ProcNatlAcadSciUSA. 2000; 97(7):3260-5.
Dalla-Favera R, et al. “Cloning and characterization of different human sequences related to the onc gene (v-myc) of avian myelocytomatosisvirus (MC29).” ProcNatlAcadSciU S A. 1982;79:6497–501
Ellwood-Yen, Katherine et al. “Myc-driven murine prostate cancer shares molecular features with human prostate tumors.” UClA.
Hatton, Kimi S et al. “Expression and Activity of L-Myc in Normal Mouse Development.” Molecular and Cellular Biology. 1996; 16:4, 1794-1804
Henriksson, Marie and Marina Vita. “The Myc oncoprotein as a therapeutic target for human cancer.” Seminars in Cancer Biology.2006; 16, 318-330
Laurenti, Elisa et al. “Hematopoietic Stem Cell function and Survival Depend on c-myc and N-myc activity.” Cell Stem Cell. 4 Dec 2008; 3:6, 611-624
Nesbitt, Chad et al. “Myc Oncogenes and human neoplastic disease.” Oncogene. 13 May 1999; 18:19, 3004-3016
Penn, Linda Z and Amanda R. Wasylishen. “Myc: The Beauty and the Beast.” Genes and Cancer. 26 July 2010;
Wey, Alice et al. “c- and N-myc Regulate Neural Precursor Cell Fate, Cell Cycle, and Metabolism to Direct Cerebellar Development.” Cerebellum. Dec 2010; 9:4, 537-547