Welcome to Pritzker Summer Research Program

1. Welcome to Pritzker Summer Research Program University of Chicago

2. Objective #1: Conduct research Prepare you to conduct mentored- research projects Mentor Mentor�s staff and faculty collaborators Cluster group leaders Peers Offer input on progress Sounding board

3. Objective #2: Get Inspired Inspire you to want to do research  June 20th 10am Neil Shubin, PhD Associate Dean, Organismal Biology & Anatomy Provost,�The Field Museum Best selling author!

4. Objective #3: The Paper Provide a framework for scientific writing References (Deb Werner) Introduction Methods

5. Before you write Who are you writing for? Goal: to identify �target� journal Readership Impact factor

6. Next� Download instructions for authors VERY detailed Follow format Word limit Table/Figure Reference Subheadings First page specify the journal format you are using

7. Can�t decide? Use JAMA original research as default Chicago-based, high impact, general audience Maximum word limit of 3000 words 5 Tables/Figures Double spaced Easy on the eyes for the reviewers (including me!)

8. This is not �creative writing�

9. IMRaD Unlike a novel, newspaper article or an essay�a scientific paper has a required structure and style By international consensus "Introduction Methods Results and Discussion" or IMRaD

10. Introduction Opening line Start broad with something that interests your audience �the hook� But not too broad �Sleep is a required biological function� Could frame it as a problem with scope �Sleep deprivation is a common problem worldwide� Funnel method to end with your specific aim and your hypothesis

11. Introduction Routinely 2 to 3 paragraphs Think about the 3 main items that someone needs to know to understand your aim Each of these items could be a separate paragraph Create topic sentences for each paragraph carefully that introduce the next idea Need good �flow� Transition words and phrases between ideas

12. Transitions Words Similar idea In addition Furthermore Moreover also Likewise Similarly As a result For example Opposite idea However Nevertheless In contrast Regardless

13. Strategic References Avoid �reference rehash� �Chang et al showed X. Towle et al demonstrated Y. Alexander et al demonstrated Z.� OK to do this for 1-2 landmark studies Goal is to synthesize prior work �Prior studies have showed�� �Some studies showed that X�. In contrast, other studies showed Z.�

14. Create tension or �gap� Given that other studies have taken place, why is your study needed Highlight potential links to therapy, policy, scientific discovery

15. Pitfalls of Introduction Too long Reference rehash or overlaod Not making the case for the study � WHY? Jargon or abbreviations not explained Too broad Poor flow

16. Methods Step by step detailed protocol In general, 3 main paragraphs Study Design Data Collection Data Analysis

17. Study Design�including Setting & Population Design Retrospective or prospective? RCT, pre-post, observational? Setting: Where conducted? Multicenter, single institution, in a lab, in the community. Population: Who or what was studied? People, cell lines, etc. In enough detail so reader can assess generalizability Often end with IRB/IACUC approval or exemption statement

18. Data Collection Step by step, how was data collected May use sub-sub headings if many types of methods Give examples how a survey question was worded & scale used Describe any products/instruments used (inc manufacturer) and units reported Reference studies that use these methods or validate these methods Past tense (since ideally it was done!)

19. Data Analysis Calculations used to arrive at the results Data were analyzed using.. . Specific tests Qualitative or Quantitative Any software or product used How statistical significance was defined Multiple comparisons may necessitate more conservative p values

20. Pitfalls of Methods No data analysis section due to a fear of statistics Too short Not enough detail to understand study Assuming that others know what your method is No mention of IRB/IACUC No methods references

21. Conquering Fear of Statistics FIRST use your mentor and resources of your mentor�s lab, Dept, colleagues etc. May have a statistician for the project Or someone they curbside for stats questions Revisit notes from Dr. Lauderdale�s class If your mentor needs help� biostatistics assistance available to faculty (and their students) Save for when you need it �at critical point Costs $$$ after 2h of use (to your mentor) http://biotime.uchicago.edu/

23. STATA and other software During the Winter, STATA is provided FREE of charge (thanks to Dr. Lauderdale and her team!) to avoid licensing fees licenses would expire by Summer Your mentor is responsible for providing you with the statistical programs & resources you need to carry out research Usually done via computer in their lab with software

24. Want STATA after hours? Visit the Library! Beware PHI & leaving research info on the computer Load on PERSONAL computer

26. SRP ? S&D Project?

28. Common Issues in SRP Mentor NOT available Plan ahead Find out who the other resources in the �lab� are Make it easy for them (phone, email, meet them in clinic)

29. Project not working? It is OK if� Hypothesis is disproven p value is >0.05 enrollment is low results are slow

30. What are the hours? Expectation is to contribute full-time Natural ebb & flow May feel like its easy now� �Crunch time� as final paper & presentation nears Plan ahead

31. Too much free time? Talk to your mentor Related project Troubleshoot difficulty Work ahead Paper Power point (Aug lecture)

32. START Program Scholars in Translational Aging Research Training Program sponsored by the National Institutes on Aging Hear about different research & clinical topics related to aging Monday mornings but ends before �crunch time� (Jun 20th to Aug 1st) Sign up sheet GOING around OR email kblythe@bsd.uchicago.edu

33. Logistics Cluster Group Student liaisons help arrange meeting & communicate with student Groups named by dominant themes or leader expertise Note down presentation date/time Invite mentor, family & friends Payment � increased to $5400!! Made in 2 installments mid & end of summer Requires assignments completed

34. Uploading Assignments http://srp.uchicago.edu

35. SRP Questions

36. Questions?