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Tissue Repair - PowerPoint PPT Presentation


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Tissue Repair. Regeneration of injured cells by cells of same type, for example regeneration of skin/oral mucosa Replacement by fibrous tissue ( fibroplasia , scar formation) Both require cell growth, differentiation, and cell-matrix interaction. Varieties of Proliferative Potential.

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slide2

Regeneration of injured cells by cells of same type, for example regeneration of skin/oral mucosa

Replacement by fibrous tissue (fibroplasia, scar formation)

Both require cell growth, differentiation, and cell-matrix interaction

varieties of proliferative potential
Varieties of Proliferative Potential
  • Stable (quiescent) cells:
    • Normally little proliferation but remain capable of more rapid cell division following injury.
    • Liver, kidney, pancreas, endothelium, fibroblasts
    • Chances of regeneration are GOOD
varieties of proliferative potential1
Varieties of Proliferative Potential
  • Labile (always dividing) cells:
    • Replace dying cells
    • Epithelial cells of the skin, oral cavity, exocrine ducts, and GI tract; endometrial and bone marrow cells.
    • Chances of regeneration are EXCELLENT
varieties of proliferative potential2
Varieties of Proliferative Potential
  • Permanent (non-dividing ) cells:
    • Not capable of proliferation.
    • Irreversible injury leads only to scar
    • Nerve cells, myocardium, skeletal muscle,
cell signaling patterns
Cell Signaling Patterns
  • Autocrine = ligand is secreted and detected by same cell
  • Paracrine = ligand is secreted and separately detected by neighboring cells
  • Endocrine = ligands (usually hormones) are secreted into the vasculature to affect distant target cells
healing by first intension primary
Healing by first intension (primary)
  • This occurs in clean, incised wound with good apposition of the edges.
healing by second intension secondary
Healing by second intension(secondary)
  • This occurs in open wound, particularly when there has been significant loss of tissue , necrosis or infection
fibrosis
FIBROSIS
  • Fibrosis, in general, refers to any fibroblast proliferation with deposition of excess extracellular matrix which is mostly collagen.
  • Leads to functional loss.
  • It is the end result of wound healing
slide20

This is a healing biopsy site on the skin seen a week following the excision, The skin surface has re-epithelialized, and below this is granulation tissue with small capillaries and fibroblasts forming collagen.

complications of wounds
Complications of Wounds
  • Deficient scar formation – wound dehiscence/ ulceration
  • Excess repair – keloid formation
  • Excess contraction – joint contractures/ intra-abdominal adhesions