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Program Goals. Gastric and Esophageal Cancer in the United States, 2013. Gastric Cancer Incidence: Geographic Differences. Gastric Adenocarcinoma: Heterogeneous Diseases. Gastric Cancer: Death Rates in the United States. Subcardial Gastric Cancer Incidence: Trends Among Different Age Groups.

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Program Goals


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    Presentation Transcript

    1. Program Goals

    2. Gastric and Esophageal Cancer in the United States, 2013

    3. Gastric Cancer Incidence: Geographic Differences

    4. Gastric Adenocarcinoma: Heterogeneous Diseases

    5. Gastric Cancer: Death Rates in the United States

    6. Subcardial Gastric Cancer Incidence: Trends Among Different Age Groups

    7. Gastric Adenocarcinoma: Heterogeneous Diseases

    8. Esophagogastric Adenocarcinomas: Pathologic Distinctions

    9. Pathogenesis of Esophagogastric Adenocarcinomas

    10. Gastric Cancer: Molecular Subtypes With Distinct Expression Profiles

    11. Gene Signature Validated in Primary Gastric Cancers: 2 Patient Cohorts

    12. Identifying Relevant Biologic Targets to Guide Therapeutic Development

    13. Significantly Mutated Genes in Whole-exome Sequencing Studies

    14. Exome Sequencing in GEJ and Esophageal Adenocarcinoma

    15. Candidate Biologic Pathways in Gastric Cancer

    16. Gastric Cancer: Single-Agent Chemotherapy

    17. Chemotherapy Regimens for Metastatic Esophagogastric Cancer

    18. HER/ErbB Family in Gastric Cancer

    19. ToGA: Phase 3 Trial of Trastuzumab in First-line Gastric/GEJ Cancer

    20. ToGA Primary End Point: OS

    21. ToGA Efficacy: OS by Subgroup Analysis

    22. HER2- Expression Frequency by Histologic Subtype

    23. T-DM1 Structure

    24. HER/ErbB Targeting in Gastric Cancer

    25. Rilotumumab in First-line Gastric/GEJ Cancer: Phase 2 Trial

    26. Rilotumumab Efficacy in ITT Population

    27. Rilotumumab Efficacy in MET-High Population

    28. Role of VEGF Pathway in Tumor Growth

    29. VEGF Expression Associated With Worse Survival in Gastric Cancer

    30. AVAGAST: Bevacizumab in First-line Gastric/GEJ Cancer - Phase 3 Trial

    31. AVAGAST Primary End Point: OS

    32. Role of VEGF Pathway in Tumor Growth

    33. Neovascularization and VEGFR2 Expression from Barrett’s to Esophageal Adenocarcinoma

    34. Anti-VEGFR2 MAb in a Gastric Cancer Animal Model

    35. REGARD: Ramucirumab Monotherapy in Second-line Gastric/GEJ Cancer, Phase 3 Trial

    36. REGARD: Efficacy Results

    37. RAINBOW: Ramucirumab in Second-line Gastric/GEJ Cancer, Phase 3 Trial

    38. Summary and Conclusions

    39. Summary and Conclusions (cont)

    40. Abbreviations

    41. Abbreviations (cont)

    42. Abbreviations (cont)