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Improving Outcomes in Cancer Cachexia: Nutrition, Treatments, and Patient Symptoms

This program explores the comprehensive management of cancer-related cachexia, emphasizing the importance of understanding and addressing patient-reported end-of-life symptoms such as loss of appetite and weight loss. It covers the underlying mechanisms of cachexia, including the role of the ubiquitin-proteasome system, and presents evidence-based interventions. Key topics include parenteral nutrition, oral feeding strategies, and pharmacological treatments like megestrol acetate and anamorelin. The program also highlights new avenues of investigation aimed at enhancing body composition and overall quality of life for cancer patients.

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Improving Outcomes in Cancer Cachexia: Nutrition, Treatments, and Patient Symptoms

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Presentation Transcript

  1. Program Goals

  2. Introduction

  3. Program Outline

  4. Patient-reported End-of-life Cancer Symptoms

  5. Loss of Appetite Affects Survival

  6. Effect of Weight Loss on Survival

  7. Body Composition Changes in Cancer

  8. Consequences of Cachexia

  9. Definition and Classification of Cancer CachexiaAn International Consensus

  10. Ubiquitin-Proteasome System

  11. Cachexia is Not Starvation

  12. Program Outline

  13. Parenteral Nutrition

  14. Meta-analysisTPN for Cancer Patients Receiving Chemotherapy

  15. Effect on SurvivalOral Feeding for Malnourished Cancer Patients

  16. Approach to the Patient With Cachexia

  17. Megestrol Acetate Dosing

  18. Megestrol Acetate vs Placebo Effect on Appetite

  19. Megestrol AcetateLimitations

  20. Despite Improvements in Appetite, Quality of Life Is Not Always Improved

  21. Program Outline

  22. New Avenues of Investigation for Treatment of Cancer-related Cachexia

  23. Antimyostatin Agents

  24. Antimyostatin TherapyImprovements in Body Weight and Survival

  25. Example of Natural Myostatin Deficiency

  26. Example of Natural Myostatin Deficiency (cont)

  27. JAK Inhibition Associated With Weight Gain in Myelofibrosis Patients

  28. Ruxolitinib for Treatment of Metastatic Pancreatic Cancer

  29. Ghrelin Analogues Anamorelin for Treatment of Cancer Cachexia

  30. Treatment With Anamorelin Improves Patient-reported Symptoms

  31. Summary

  32. Abbreviations

  33. References

  34. References (cont)

  35. References (cont)

  36. References (cont)

  37. References (cont)

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