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Nanoparticulate Material Applications to Biological Processes: Therapeutic and Toxic Effects. NSF EPSCoR A Joint Effort between UALR, ASU, UAMS, UAF. M. K. Mazumder September 20, 2005. Education, Research, and Public Outreach. Nanoaerosols. Nanomaterials Processing Media

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nanoparticulate material applications to biological processes therapeutic and toxic effects

Nanoparticulate Material Applications to Biological Processes: Therapeutic and Toxic Effects

NSF EPSCoRA Joint Effort betweenUALR, ASU, UAMS, UAF

M. K. MazumderSeptember 20, 2005

nanoaerosols
Nanoaerosols
  • Nanomaterials Processing Media
    • Liquid (Colloidal Suspensions)
    • Gas (aerosols)
  • Therapeutic Applications/Drug Delivery
    • Inhalation
    • Ingestion
    • Dermal Contact
    • Intravenous
nanoparticle interaction with environment
Nanoparticle Interaction with Environment
  • Transport and diffusion of nanoparticles in atmosphere (atmospheric chemistry)
  • Emission/Exposures
  • Interaction of nanoparticles with biological cells
  • Containment
  • Filtration
  • Health Effects (Inhalation, Ingestion, Dermal Contacts)
educational and economic goals
Educational and Economic Goals
  • Integrative Education
  • Collaboration between UALR, UAMS, ASU, UAPB, NCTR, UAF
  • Collaboration with National Laboratories (NASA, DOE)
  • Infrastructure and economic development
nano structured biomaterials
Nano-Structured Biomaterials
  • Minimize biocorrosion in implants
  • Develop biocompatible coatings
  • Drug elution and delivery using vesicles, liposomes, and nanoparticles
  • Polyelectrolyte coating of nanoparticles
  • Lotus Effect: Lubricous Catheters
  • Nanoparticle Diagnostics
biological interaction of nanoparticles toxic effects
Biological Interaction of Nanoparticles: Toxic Effects
  • Nanoparticle Inhalation Toxicity
  • Characterization of nanoparticle interactions in biological cells
  • Use of AFM and EFM to study the interaction of nanoparticles with living cells
slide8

Inhalation of Nanoparticles

GI Tract

Nanoparticles

Mucociliary clearance

Blood

Inhalation

Alterations in

cardiopulmonary

& immune systems

Nasopharyngeal Region

Other Organs

Tracheobronchial Airways

Liver,

Heart,

Brain

Fibrotic lung disease,

interstitial fibrosis &

pulmonary hypertension

Terminal Bronchiole

Alveoli & Alveolar Ducts

Blood

Translocation of inhaled nanoparticles, alteration of cardiopulmonary and immune response

nanoaerosol physics
Nanoaerosol Physics
  • Generation, size, charge, and shape characterization of nanoparticles
  • Coagulation, dispersion, condensation of vapors
  • Electrical characterization Photoemission, work function
  • Interaction with plasma
  • Adhesion and removal
nanoaerosol technology
Nanoaerosol Technology
  • Generation of metal and non-metal nanoparticles
  • Functionalization
  • Develop instruments for size and charge characterization on a single-particle basis
  • Deposition of nanoparticles on surfaces
  • Electrodynamic guided assembly of nanoparticles on micron-sized particles levitated in air
nanoparticulate material applications
Nanoparticulate Material Applications
  • Human missions to the Moon and Mars
  • Dust hazard control and respiratory protection
  • Bioengineered Respiratory Drug Delivery (Prophylaxis for biodefense – antibiotic, antitoxin, antibody)
  • Respiratory drug delivery of protein, DNA-carrying nanoparticles