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Nanoparticulate Material Applications to Biological Processes: Therapeutic and Toxic Effects

Nanoparticulate Material Applications to Biological Processes: Therapeutic and Toxic Effects. NSF EPSCoR A Joint Effort between UALR, ASU, UAMS, UAF. M. K. Mazumder September 20, 2005. Education, Research, and Public Outreach. Nanoaerosols. Nanomaterials Processing Media

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Nanoparticulate Material Applications to Biological Processes: Therapeutic and Toxic Effects

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  1. Nanoparticulate Material Applications to Biological Processes: Therapeutic and Toxic Effects NSF EPSCoRA Joint Effort betweenUALR, ASU, UAMS, UAF M. K. MazumderSeptember 20, 2005

  2. Education, Research, and Public Outreach

  3. Nanoaerosols • Nanomaterials Processing Media • Liquid (Colloidal Suspensions) • Gas (aerosols) • Therapeutic Applications/Drug Delivery • Inhalation • Ingestion • Dermal Contact • Intravenous

  4. Nanoparticle Interaction with Environment • Transport and diffusion of nanoparticles in atmosphere (atmospheric chemistry) • Emission/Exposures • Interaction of nanoparticles with biological cells • Containment • Filtration • Health Effects (Inhalation, Ingestion, Dermal Contacts)

  5. Educational and Economic Goals • Integrative Education • Collaboration between UALR, UAMS, ASU, UAPB, NCTR, UAF • Collaboration with National Laboratories (NASA, DOE) • Infrastructure and economic development

  6. Nano-Structured Biomaterials • Minimize biocorrosion in implants • Develop biocompatible coatings • Drug elution and delivery using vesicles, liposomes, and nanoparticles • Polyelectrolyte coating of nanoparticles • Lotus Effect: Lubricous Catheters • Nanoparticle Diagnostics

  7. Biological Interaction of Nanoparticles: Toxic Effects • Nanoparticle Inhalation Toxicity • Characterization of nanoparticle interactions in biological cells • Use of AFM and EFM to study the interaction of nanoparticles with living cells

  8. Inhalation of Nanoparticles GI Tract Nanoparticles Mucociliary clearance Blood Inhalation Alterations in cardiopulmonary & immune systems Nasopharyngeal Region Other Organs Tracheobronchial Airways Liver, Heart, Brain Fibrotic lung disease, interstitial fibrosis & pulmonary hypertension Terminal Bronchiole Alveoli & Alveolar Ducts Blood Translocation of inhaled nanoparticles, alteration of cardiopulmonary and immune response

  9. Nanoaerosol Physics • Generation, size, charge, and shape characterization of nanoparticles • Coagulation, dispersion, condensation of vapors • Electrical characterization Photoemission, work function • Interaction with plasma • Adhesion and removal

  10. Nanoaerosol Technology • Generation of metal and non-metal nanoparticles • Functionalization • Develop instruments for size and charge characterization on a single-particle basis • Deposition of nanoparticles on surfaces • Electrodynamic guided assembly of nanoparticles on micron-sized particles levitated in air

  11. Nanoparticulate Material Applications • Human missions to the Moon and Mars • Dust hazard control and respiratory protection • Bioengineered Respiratory Drug Delivery (Prophylaxis for biodefense – antibiotic, antitoxin, antibody) • Respiratory drug delivery of protein, DNA-carrying nanoparticles

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