HERPES GENITALIS & SYPHILIS

1. HERPES GENITALIS & SYPHILIS Mia Smoljan Mentor: A. Žmegač Horvat

2. Herpes genitalis • STD caused by HSV • Remissions and relapses • Symptoms: • reddening of the skin with small, fluid-filled blisters and ulcers • initial episodes may be more severe – inguinal lymphadenopathy, fever, malaise, headache • Diagnosis: • PCR • Tzank test • Treatment: Acyclovir

3. http://www.youtube.com/watch?v=TY8XhAKI7CI/

4. Herpes neonatalis • Dangerous complication that affects babies born while mother has an active infection during parturition • Symptoms appear between 1st and 2nd week of life • Can affect: • skin • CNS • eye • mouth • liver • lungs • ........ • Prevention: Cesarean section • Treatment: Acyclovir

5. Syphilis • Chronic STI caused by Treponema pallidum • Acquired via direct sexual contact with the infectious lesions of a person with syphilis • PRIMARY SYPHILIS: a few weeks after infection • chancre/hard ulcer • after 4 to 6 weeks heals spontaneously

7. SECONDARY SYPHILIS: • 1–6 months (commonly 6 to 8 weeks) after the primary infection • symmetrical reddish-pink non-itchy rash on the trunk and extremities • condylomata lata(rash becomes flat, broad, whitish lesions) • most contagious stage!! • meningismus, enlarged lymph nodes, fever....

9. TERTIARY SYPHILIS: • 1–10 years after the initial infection • formation of gummas= • soft, tumor-like balls of inflammation –granulomas • neuropathic joint disease • neurosyphilis • tabes dorsalis • cardiovascular syphilis – ascending aorta!! • cor bovinum

10. Diagnosis: serology (VDRL antibody test, TPHA) • Treatment: • penicillin