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Single Fiber Polymorphism in Skeletal Muscles: A Case Example from the Lobster

Single Fiber Polymorphism in Skeletal Muscles: A Case Example from the Lobster. Scott Medler. Wolfe, 1985 Cell Ultrastructure. Guyton and Hall 1996 Textbook of Medical Physiology 9th Ed. Guyton and Hall 1996 Textbook of Medical Physiology 9th Ed. Guyton and Hall 1996

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Single Fiber Polymorphism in Skeletal Muscles: A Case Example from the Lobster

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  1. Single Fiber Polymorphism in Skeletal Muscles: A Case Example from the Lobster Scott Medler

  2. Wolfe, 1985 Cell Ultrastructure

  3. Guyton and Hall 1996 Textbook of Medical Physiology 9th Ed.

  4. Guyton and Hall 1996 Textbook of Medical Physiology 9th Ed.

  5. Guyton and Hall 1996 Textbook of Medical Physiology 9th Ed.

  6. S1/S2 MHC expression

  7. Tm expression vs. MHC expression (mRNA)

  8. TnT3 protein vs. S1/S2 MHC mRNA

  9. TnI3 protein vs. S1/S2 MHC mRNA

  10. TnI2 protein vs. S1/S2 MHC mRNA

  11. CONTINUUM OF ISOFORM EXPRESSION S1 fibers S2 fibers = high expression = low expression S1 MHC S2 MHC TnT3 TnT1 TnI3 TnI2 S1 Tm S2 Tm

  12. Immediate Research Focus: Single fiber polymorphism in lobsters • Developmental changes in fiber phenotype • Mechanical measurements from single fibers • Innervation pattern and fiber phenotype • Effects of electrical stimulation on fiber phenotype

  13. Long Term Research Interests: • Single Fiber Polymorphism in Mammals • Scaling Effects on Cellular/Molecular Organization of Muscles • Physiology of Avian Flight Muscles

  14. Acknowledgements: National Institutes of Health: Postdoctoral fellowship AR 08597-01A1 to S. Medler National Science Foundation: IBN-0077422 to D.L. Mykles Dr. D.L. Mykles Colorado State University Travis Lilley Colorado State University

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