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This study examines the impact of SB202190 treatment on cell viability in pancreatic cells under varying oxygen conditions. Findings reveal increased cell survival with SB202190 treatment. This research sheds light on potential therapeutic strategies for pancreatic diseases.
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A Panc5.04 A10.7 A38.44 *** ** *** *** *** ** ** ** B C Panc5.04 A38.44 ADM NDRG-1 *** ** ** Vehicle (10%FBS) Vehicle (1%FBS) SB202190 (10%FBS) SB202190 (1%FBS) Vehicle (10%FBS) Vehicle (1%FBS) SB202190 (10%FBS) SB202190 (1%FBS) Vehicle (10%FBS) Vehicle (1%FBS) SB202190 (10%FBS) SB202190 (1%FBS) Vehicle 20% O2 Vehicle 1%O2 SB202190 20% O2 SB202190 1%O2 Vehicle 20% O2 Vehicle 1%O2 SB202190 20% O2 SB202190 1%O2 *** * Fold Change Relative to Normoxia ** ** ** *** *** ** * *** * Panc5.04 A38.44 Supplemental Figure 4