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Cellular Responses to Radiation and Treatment in SQ20B Cells

Investigating the kinetics of ALDH induction, Bmi-1, beta-catenin, and Notch expression in SQ20B and SQ20B/SP/CD44+/ALDH+ cells following irradiation and treatment. Identifying changes in gene expression after exposure to UCN-01 and ATRA alone or in combination.

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Cellular Responses to Radiation and Treatment in SQ20B Cells

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  1. ** * Supplementary Figure 1 : Kinetics of ALDH induction in the SQ20B cell line after a 10Gy photon irradiation . *p<0.05, **p<0.01, and ***p<0.001 compared to controls. B A C Supplementary Figure 2 : Kinetics of Bmi-1 (A), b-catenin (B) and Notch (C) expression in the SQ20B/SP/CD44+/ALDH+ cells after a 10Gy photon or 5Gy carbon irradiation

  2. B A Relative Gene expression of Bmi-1 Relative Gene expression of Notch Supplementary Figure 3 : Relative gene expression of Bmi-1 (A) and Notch (B) in the SQ20B/SP/CD44+/ALDH+ cells after treatment or not with UCN-01 / ATRA or ATRA+UCN-01 1 and 24h after a 10Gy photon

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