Wound Healing Pharmaceuticals: What the EBM Tells Us. Robert G. Smith DPM., MSc., R.Ph., C.Ped PharmCon 2008 Pharmcon is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. Learning Objectives.
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Robert G. Smith DPM., MSc., R.Ph., C.Ped
Pharmcon is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education
Diagnosed: 14.6 million people
Undiagnosed: 6.2 million people
Approximately 15% of patients with diabetes will have a foot ulcer and those who develop an ulcer, 6% will be hospitalized due to infection or other ulcer related complicationsPrevalence of Diabetes Mellitus
Studies focused on dressings as related to wound type and cost factors
Luker & Kenrick 1992
Bux & Malhi 1996
Vermeulen et 2006Central Dressing Selection Theme
No association with the use of tap water and an increase rate of infection.
Angeras et al conducted a randomized study comparing the use of tap water with saline to cleanse acute traumatic soft tissue injuries.
Lower rate of infection in those wounds where tap water had been used to cleanse wounds; 5.4% with tap water compared to 10.3% with the saline group.
Bansal et al and Valente et al compared tap water and saline wound irrigation of simple lacerations in pediatric patients.
Bansal et al performed a blinded investigation while Valente et al conducted an unblinded non-randomized investigation.
Despite positive post irrigation cultures were found in Bansal et al’s investigation and clinical determination of infection in Valente et al’s study determined these findings were not significantly different between the normal saline solution and tap water groups.Clinical Trials on Tap Water
gelatin, pectin, elastomers, and adhesives) bound to polyurethane foams that are impermeable to bacteria and facilitating wound debribement