Chronic myeloid leukemia. The myeloproliferative diseases (MPDs) are clonal stem cell disorders characterised by leukocytosis, thrombocytosis, erythrocytosis, splenomegaly, and bone marrow hypercelularity
How does one treat the younger CML patients with a possible allogeneic donor?
Vincristine sulfate 1,4mg/m² iv once per week
+ prednisone 60mg/m² per day orally
one-third of patiens reenters the chronic phase, but remission lasts usually about 4 months