Acute myeloid leukemia . Malignant clonal disorder of immature hematopoietic cells characterized by ab b erant hematopoietic cellular proliferation and maturation. Leukamic blasts may express capabilities for maturation to a variable degree,
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supression of normal hematopoietic progenitor cells growth granulocytopenia, thrombocytopenia and anemia
*in the treatment of AML-M3 all-trans retinoic acid is also used
and restoration of polyclonal hemopoiesis
* defined as reduction of the blast cells in the marrow < 5% (inapparent) and normalzation of the picture of the peripheral blood
However, monoclonal hemopoiesis is still present!
AML-M4 or 5
patients < 18 years old
combination of drugs administered intrathecally
(Ara-C plus Fenicort, MTX plus Fenicort)
The aims of the intensification treatment:
- elimination of residual disease
-abnormalities of chromosome 5, complex changes, monosomy 7 and 3q-