conditional inactivation of noggin in the postnatal skeleton causes osteopenia n.
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Conditional inactivation of Noggin in the postnatal skeleton causes osteopenia. Osteoscoop - Issue N°243 – June 2012. Noggin. BMP-2. Smad. +. Sclerostin. Osteoblast. Lower weight. Shorter femoral length. Generalized osteopenia. Noggin D /+. Noggin D /-. Noggin. BMP-2. Smad. +.

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conditional inactivation of noggin in the postnatal skeleton causes osteopenia

Conditional inactivation of Noggin in the postnatal skeleton causes osteopenia

Osteoscoop - Issue N°243 – June 2012

slide2

Noggin

BMP-2

Smad

+

Sclerostin

Osteoblast

slide3

Lower weight

Shorter femoral length

Generalized osteopenia

NogginD/+

NogginD/-

Noggin

BMP-2

Smad

+

Sclerostin

Osteoblast

slide4

Lower weight

Noggin

Low bone formation

Wnt signaling

BMP-2

Shorter femoral length

Smad

+

Sclerostin

Generalized osteopenia

Osteoblast

NogginD/+

NogginD/-