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Beginning of systole Valve opening

Biomedical Applications of Crosslinked Aerogels Wei Yin, Oklahoma State University, DMR 0907291. Untreated. Plasma treated. Beginning of systole Valve opening. Carbon.

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Beginning of systole Valve opening

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  1. Biomedical Applications of Crosslinked AerogelsWei Yin, Oklahoma State University, DMR 0907291 Untreated Plasma treated Beginning of systole Valve opening Carbon • The dysprosium aerogels are the top candidate for artificial heart valves, due to their excellent biocompatibility, structural stability and matching mechanical strength compared to pyrolytic carbon. • A 3D Fluid Structure Interaction model was developed to optimize the design of a monoleaflet aerogel heart valve. At the opening angle of 75, the hemodynamic performance of the aerogel valve was comparable to that of a St. Jude bileaflet mechanical heart valve, the most popular mechanical heart valves in the US market. • Dysprosium aerogels are also suitable for sustained drug release systems. Aerogel End of systole Valve closing Load-displacement relationship of pyrolytic carbon and dysprosium aerogels. Figure on the left: Velocity streamline around the aerogel valve as the valve opens and closes during systole, with the optimal opening angle of 75. SEM images of dysprosium aerogels. 24-hour incubation with plasma did not induce any noticeable changes in dysprosium aerogel structure, compared to untreated samples. Figure on the left: Drug release in PBS as a function of time in (A) a polyurea crosslinked aerogel, and (B) crosslinked dysprosium aerogel.

  2. Biomedical Applications of Crosslinked AerogelsWei Yin, Oklahoma State University, DMR 0907291 • Dr. Hongbing Lu mentored a high school student team (Justin Zhong, Thomas Lu and Kevin Lin) to work on mesoporous materials, and the team won the second prize in chemistry category in 2012 Texas high school science fair. • The PIs on this project have all contributed to the Aerogels Handbook (Advances in sol-gel derived materials and technologies), ISBN 1441974776. • Many undergraduate students are involved in the aerogel project and a good number of them are female engineering students. 400 students in grades 7-12 entered the Texas Encana-Plano ISD secondary district science fair in 2012. Picture is from the Plano Independent School District News. http://www.pisd.edu/news/archive/2011-12/science.fair.secondary.district.shtml Graduate students showing undergraduate students different types of aerogels

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