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Geant4 Simulation Study for Proton Therapy

Geant4 Simulation Study for Proton Therapy. Proton Therapy Center. Se Byeong Lee Medical Physicist, Ph.D. The 3 rd FKPPL workshop , March 8-9, 2011, Seoul , Korea.

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Geant4 Simulation Study for Proton Therapy

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  1. Geant4 Simulation Study for Proton Therapy Proton Therapy Center Se Byeong Lee Medical Physicist, Ph.D. The 3rd FKPPL workshop , March 8-9, 2011, Seoul, Korea

  2. History1989. 12. Plan to establish NCC formulated by Ministry of Health and Welfare1997. 7. Construction of NCC Hospital building completed2000. 10. NCC started clinical care services 2005. 2. Proton Therapy Facility Installation 2005. 10. First Beam Production2007. 3. First Proton treatment start 2010. 12 648 patients treated in Proton Therapy Facility Overview of NCC

  3. Facilities in Research Institution

  4. Proton beam facility in NCC • Proteus 235 Specification • Weight : 220 ton Height : 210 cm Diameter : 434 cm • Energy : 230MeV • Max. extracted beam current : 300nA • RF frequency :106 MHz

  5. Beam delivery Uncertainty Target Ex.) 5mm beam off on Target (1 portal) - Proton : 100%  0% dose - Photon : 100%  > 95% dose

  6. Uncertainties on Proton Treatment Planning MGH study

  7. Motivation of MC Simulation Study for Proton Therapy • Proton Treatment Planning : Accurate dose calculation ? • Radiation Shielding : Patient & worker safety ? • Patient simulation (Respiratory gating) : 4D Dose distribution ? • Beam Nozzle simulation : Design study, QA ?  Monte Carlo Simulation

  8. MC simulation of Proton Beam System • Modeling • Modeling Nozzle • Modeling Treatment scheme • User interface for M.C set-up • Convalgo (“Conversion Algorithm” by IBA) interface • Validation • Geant4 physics test on CSDA rangeand non-elastic interaction probability • Bragg peaks comparison • Conversion function (Range2MCEnergy) • Applications • SOBP reproduction for Proton therapy

  9. 1. Modeling - nozzle Framework libraries User applications

  10. Measurement Rp (Range in Patient), SOBP Monte Carlo Scatterers setting Variable collimator opening R.M wheel with BCM database Snout positioning Cyclotron energy, current ... 2. User Interface input CONVALGO output Treatment Control System (TCS) - not clinical mode /GTR2/SNT/type 250 /GTR2/SNT/aperture/rectangle open /GTR2/SNT/aperture/rectangle Lx Ly Ox Oy #Geant4 kernel initialize /run/initialize /GTR2/FS/lollipops 9 5 /GTR2/SS/select 3 /GTR2/RM/track 5 /GTR2/RM/angle 80.26 /GTR2/VC/setVxVy cm 14.2 15.2 /BTS/particle proton /BTS/energy E MeV 181.8 1.2 /BTS/geometry mm 3 5 /BTS/emittance G mm 1.5 /TCS/passive/BCM TR2_B6_1 144 1000/TCS/StartIrradiation BCM pattern Init. Beam configuration Nozzle configuration BTS : BeamTransportSystem, TCS : TreatmentConstrolSystem

  11. 3. Validation test of Nozzle Modeling Geant4 version: 8.2.p01 - EM model : G4hIonization with ICRU49 parameterized table - Hadronic : LHEP_PRECO_HP ( precompound model ) MC Simulation NCC Proton Beam Delivery MC Simulation

  12. 4. Application : Proton Treatment Beam MC Sim. • variousbeam mode modeling • DICOM datahandling • Dose calculation using Geant4 MC simulation

  13. 4. Application : Medical Imaging tool (gMocren – KEK) Patient CT Image Reconstruction Proton beam irradiation simulation on a Patient body with CT image

  14. FKPPL VO Grid Testbed VOMS WIKI CE UI CE LFC WMS SE SE FKPPL VO IN2P3 KISTI

  15. JOB Performance test on GRID

  16. PMB 2004 J.J. Wilkens (keV/um) Motivation : Relative Biological Effectiveness [Figure courtesy of J.Gueulette, redrawn from the data of Menzel et al., 1990, Loncol et al., 1994, and Gueulette et al, 2004].

  17. Proton RBE Measurement in NCC, Korea Plating HSG Locating Cell holder in 50 fields Assembling Cell holder Cover Slide Proton Beam Stacking Chamber Removing Cell holder Trypsin Digestion 2 - 3 Weeks Counting Colony Replating in Culture Dish

  18. Cell Survival in Depth

  19. Measurement of DNA Breaks (Preliminary Exp.) DNA Break (arb. value) 5ul of Plasmid DNA sample Gy Proton beam Dose DNA Break measurement with Electrophoresis 0, 25, 50, 100, 200 Gy of Proton Beam (5 g/cm2 at 210 MeV)

  20. The collaboration Meeting On March 10, 2011 in NCC

  21. Summary • Geant4 simulation is useful and essential for Proton therapy study in NCC. • Geant4-DNA study for the calculation of proton RBE. • NCC Geant4 Study with FKPPL & FJPPL VO. - Geant4-DNA (Sébastien Incert, IN2P3 - CENBG) - GRID (Soonwook Hwang, KISTI) - Geant4-ParticleTherapy(Takashi Sasaki, KEK) • Extension of the collaboration with Gate & Radiobiology study(?).

  22. Thank you! National Center for Cancer Prevention and Early Detection Proton Therapy Center Research Institute Hospital

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