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Project Office Update November 7, 2013 . Jacques E Rossouw. Renewal . Renewal proposal approved for further development (i.e., developing Acquisition Plan) Budget subject to availability of funds --sequester, etc. Initial approval for 3 year period

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project office update november 7 2013
Project Office Update

November 7, 2013

Jacques E Rossouw

slide2

Renewal

Renewal proposal approved for further development (i.e., developing Acquisition Plan)

Budget subject to availability of funds

--sequester, etc.

Initial approval for 3 year period

--period could be adjusted depending on outcome of BEE/Council WG

unique strengths of whi
Unique Strengths of WHI

By 2050 number of US women aged >65 will have doubled to 49 million.

CVD deaths account for 36% of total deaths in older women

By 2016 WHI projects to have 85,000 participants with mean age 83 (range 66-102), N=52K or 58% age >80.

In MRC project 21K women (including 5.8K AA, 2.2K Hispanic) by 2016

current and future mission
Current and Future Mission
  • Expand knowledge about the determinants of CVD in older women (and conversely determinants of successful aging with absence of CVD)
    • Particular focus on understudied conditions of heart failure, atrial fibrillation, periperal arterial disease, aortic stenosis
    • Fully utilize the new data and bloods from the LLS subcohort
current and future mission1
Current and Future Mission
  • Expand the study as a scientific resource for the research community
    • GWAS=32K, ExomeChip=25K, Metabochip=15K
  • Mentor young investigators
    • ~150 mentored during current renewal
    • 2010 Chicago Workshop to date has led to 21 approved manuscript proposals and 5 published papers
  • Facilitate a new generation of large simple trials
    • Cocoa and multivitamin (Manson)
    • Physical Activity (Stefanick/LaCroix)
    • Vitamin D (Jackson)
  • Continue research into utility of CMS data
selected research examples
Selected Research Examples
  • Determine whether race/ethnic differences in CVD risk are explained by SES, risk markers, genomics, life habits, medical coverage, or environmental factors
  • Determine influence of risk factors (including genomic) and exposures on heart failure (including HF with preserved systolic function), AF, AS, PAD
  • Create CVD survivor cohort by following up incident events through CMS for recurrence, morbidity/mortality, quality of care, healthcare utilization and expenditures
selected research examples1
Selected Research Examples
  • Integrate gene variants, methylation, expression, regulation, metabolome, and biomarkers in systems biology approach to CVD pathways
  • Determine influence of baseline LTL on successful aging/absence of CVD and the determinants of attrition in LTL and its association with CVD risk
some initial results dissemination and mentoring 2010 2015
Some Initial Results: Dissemination and Mentoring2010-2015
  • Total ancillary studies = 225 (April, 2013)
      • Before 2010 52% led by new investigators
      • After 2010 63% led by new investigators
  • Publications = 814 (April, 2013)
      • Before 2010 30% led by new investigators
      • Since 2010 51% led by new investigators
conclusions
Conclusions
  • WHI cohort study
    • Increasingly productive
    • Cost-effective
    • High impact (~2400 cites per year since 2010)
  • Mentoring and dissemination efforts are showing results
  • Need more focus on CVD in older women