slide1 l.
Download
Skip this Video
Loading SlideShow in 5 Seconds..
Applied Beef Cattle Breeding and Selection ------------------- Disease resistance in Cattle PowerPoint Presentation
Download Presentation
Applied Beef Cattle Breeding and Selection ------------------- Disease resistance in Cattle

Loading in 2 Seconds...

play fullscreen
1 / 11

Applied Beef Cattle Breeding and Selection ------------------- Disease resistance in Cattle - PowerPoint PPT Presentation


  • 223 Views
  • Uploaded on

Applied Beef Cattle Breeding and Selection ------------------- Disease resistance in Cattle Larry V. Cundiff ARS-USDA-U.S. Meat Animal Research Center 2008 Beef Cattle Production Management Series-Module V Great Plains Veterinary Education Center University of Nebraska, Clay Center

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about 'Applied Beef Cattle Breeding and Selection ------------------- Disease resistance in Cattle' - oshin


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
slide1

Applied Beef Cattle Breeding and Selection

-------------------

Disease resistance in Cattle

Larry V. Cundiff

ARS-USDA-U.S. Meat Animal Research Center

2008 Beef Cattle Production Management Series-Module V

Great Plains Veterinary Education Center

University of Nebraska, Clay Center

September 19, 2008

slide2

Mastitis in dairy cattle

Heritability = .10 to .20 ( Miller 1982)

Attention given to somatic cell count In selection of dairy cattle.

Bovine major histocompatability complex (BOLA) genotype has been associated with incidence of mastitis (Solbu et al., 1982)

W2 highly resistant to mastitis

W16 susceptable to mastitis

slide3

Infectious bovine keratoconjunctivitis (IBK), pinkeye

Heritability = .22 (Snowder et al., 2005)

  • Incidence fluctuates greatly from year to year ( over 20 year period, < 1% to 25% per year, generally < 10%)
  • Incidence can be greater in Herefords than other breeds (Frisch 1975; Webber and Selby, 1981; Snowder et al., 2005)
  • Incidence may be associated with greater homozygosity in Herefords
slide4

Bovine Respiratory Disease (BRD)

(Snowder et al., 2008)

Postweaning (18,112 records) - Incidence ranged from 5 to 42% in 14 year period from 1987 to 2001.

Heritability = .08 Incidence post weaning (Snowder et al., 2008)

Mean incidence by breed (deviation from Angus)

Angus 0.00

Hereford 4.23

Charolais 2.72

Gelbvieh 4.09

MARC I 1.90

MARC II 3.68

MARC III 1.08

Differences between breeds were not significant (P > .05)

slide5

CHARACTERISTICS OF FIVE SELECTION LINES FOR HIGH (H) VERSUS LOW (L) ANTIBODY PRODUCTION IN MICE (Biozzi et al., 1982)

Immuni- No. gen. Est. No.

Antigens zation to sel. Diff. Herit- independ.

Sel. used proc. limit (H/L) ability loci

I Sheep eryth. Primary 16 220 fold .20 9-11

Pigeon eryth. response

II Sheep eryth. Primary 13 103 fold .21 2-8

III Salm. typh. Secondary 16 90 fold .20 4-7

IV Salm. typh. Secondary 12 85 fold .21 2-4

V Bov. Ser. Alb. Heperimmun 7 310 fold .22 2-4

Rabbit gamma alum precip.

globulin antigen

slide6

SUMMARY OF RESULTS ON RESISTANCE OF HIGH (H) AND LOW (l) MICE TO VARIOUS INFECTIONS (Biozzi et al., 1982)

Degree of resistance

Infection Innate resistance Acquired resistance

H L H L

F berghei - - +++ + Antibody T. Cruzi+++ - n.d. -dependent N. dubius- - +++ +

immunity Rabies virus - - +++ +

T Spiralis ++ + ++ ++

S typohimurium+ ++ + ++++

Macrophage T. pestis+ ++ + ++++ dependent B. abortus suis + ++ ++ ++++

immunity L tropica + +++ n.d. n.d. S. mansoni + ++ ++++++

conclusions of biozzi et al
Conclusions of Biozzi et al.
  • High response lines were more resistant to infections dependent upon antibody immunity.
  • Low lines were more resistant to infections dependent on macrophage immunity.
  • In most cases the line that was spontaneously more resistant also was protected by vaccination to a higher degree.
slide8

All types of mild

endemic infections

macrophage

dependent

immunity

antibody

dependent

immunity

Severe epidemic

infections

Severe epidemic

infections

H X L cross

F2 hybrids

Antibody responsiveness

Macrophage activity

Theory for evolution of host parasite interaction in genetically heterogeneous populations according to inverse polygenic control of antibody production and macrophage activity (Biozzi et al., 1982)

slide9

All types of mild

endemic infections

antibody

dependent

Immunity

(favors aa

genotypes)

macrophage

dependent

Immunity

(favors AA

genotypes)

Severe epidemic

infections

Severe epidemic

infections

H X L cross

F2 hybrids

Antibody responsiveness

Macrophage activity

Under mild endemic infection – Favors Aa genotypes, extreme individuals (AA or aa) would be eliminated by susceptability to diseases dependent on macrophage (or antibody) immunity.

slide10

Effects of different degrees of dominance on phenotypic value

No

Dominance

(additive)

Partial

dominance

Complete

dominance

Over-

dominance

theory of host parasite interaction
Theory of host parasite interaction
  • Theory is consistent with effects of heterosis and benefits of crossbreeding
  • Unfortunately, selection for resistance to a specific disease may lead to resistance for one group of diseases but susceptibility for another group of diseases.
  • Specialized paternal and maternal lines may be best answer.
      • With aid of vaccination procedures in parental seedstock populations and DNA marker assisted selection,
      • It may be possible to select for one type of disease resistance in paternal lines and another type of disease resistance in maternal lines.
      • Then genetic resistance could be realized with vast majority of cattle produced commercially by mating complementary maternal and sire breeds.