slide1 l.
Download
Skip this Video
Loading SlideShow in 5 Seconds..
Academic Inventions through Multidisciplinary Collaborations between Weill Cornell Medical College and Ithaca Campuses PowerPoint Presentation
Download Presentation
Academic Inventions through Multidisciplinary Collaborations between Weill Cornell Medical College and Ithaca Campuses

Loading in 2 Seconds...

play fullscreen
1 / 13

Academic Inventions through Multidisciplinary Collaborations between Weill Cornell Medical College and Ithaca Campuses - PowerPoint PPT Presentation


  • 143 Views
  • Uploaded on

Academic Inventions through Multidisciplinary Collaborations between Weill Cornell Medical College and Ithaca Campuses. Bo Liu Division of Vascular Surgery. Translate inventions in material science to novel treatments for vascular diseases. Clinical problems. Material inventions.

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about 'Academic Inventions through Multidisciplinary Collaborations between Weill Cornell Medical College and Ithaca Campuses' - nuala


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
slide1

Academic Inventions through Multidisciplinary Collaborations between Weill Cornell Medical College and Ithaca Campuses

Bo Liu

Division of Vascular Surgery

slide2

Translate inventions in material science to

novel treatments for vascular diseases.

Clinical problems

Material inventions

Vascular Surgeons

Experimental hypotheses

Material Scientists

Vascular Biologists

slide3

O

O

O

O

H

H

H

H

O

O

N

C

C

C

C

N

*

y

x

*

N

H

N

H

H

N

N

H

H

N

N

H

2

2

2

2

Project I: DNA Carriers

Problem: Lack of safe and efficient DNA/RNA carriers for molecular therapy.

Hypothesis: Newly invented PEA polymers are capable of binding DNA and delivering it to vascular cells and tissues.

PEA polymer

Cornell University Seed Grant (Liu & Chu)

11/1/06-10/31/07

Novel biodegradable biomaterials as non-viral gene transfer systems.

slide4

healthy

15 μg PEA

1,500 μg PEA

unhealthy

15 μg Superfect®

15 μg PEI

Cytotoxicity

SMC

Control – no transfection

outcome grant proposals
Outcome: grant proposals
  • NIH R21/R33 submitted on 9/16/07

Novel biodegradable polymers as non-viral gene transfer systems.

Liu, Kent, Rafii, and Chu

  • The Uehara Memorial Foundation (Japan)

Research Fellowship----- 1/01/08 to 12/31/09

Yamanochi

outcome publication
Outcome: publication

Transfection of Vascular Smooth Muscle Cells with Novel Biodegradable Arginine Based Poly(ester-amide)s

Dai Yamanouchi, M.D., Ph.D.,1, Jun Wu,2, Andrew Lazar,1, K Craig Kent, MD.,1, Chih-Chang Chu, Ph.D.,2, Bo Liu, Ph.D.1.

  • Weill Medical College; 2. Cornell University

Submitted to Molecular Therapy

slide10

Project II: Tissue engineering of blood vessels

Problem: Synthetic arterial grafts fail due to restenosis.

Approach: Using biodegradable materials as scaffold to generate blood vessels ex vivo or in vitro.

Morgan Seed Grant (Chu, Peinhart-King, Liu, and Kent)

7/1/07-12/31/08

Novel biodegradable scaffolds for tissue engineering of blood vessels.

slide11

Chu: Human Ecology

Synthesis of PEA-based biodegradable and biofunctional elastomeric scaffolds

Feedback for optimization of design parameters

Reinhart-King: BMEIn vitro engineering of scaffolds & cell adhesion study using vascular cells

Liu/Kent: WeillMedical Optimization using stem-cell mediated healing to enhance success of engineered grafts

Liu/Kent: WeillMedicalIn vivo animal model & implantation

future plan
Future Plan
  • NIH: PAR-06-504 (R01)

Enabling Technologies for Tissue Engineering and Regenerative Medicine

Projected submission date: 9/10/08

  • Industry grants
  • Patents
slide13

Vascular Surgery Lab

K. Craig Kent, MD

Bo Liu, PhD

Rachel Elden

Brad Herman, PhD

Kaori Kato, MD

Rishi Kundi, MD

Sebastian Schuble, MD

Shirling Tsai, MD

Chunjie Wang

Dai Yamanouchi, MD, PhD

Fan Zhang, MD, PhD

Andrew Zohlman

Ithaca

C.C. Chu, PhD

Hua Song, PhD

Jun Wu

Department of Surgery

Research and Sponsored Program

Caren A Heller, MD

Cornell Intercampus Seed Grant

Morgan Seed grant