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Academic Inventions through Multidisciplinary Collaborations between Weill Cornell Medical College and Ithaca Campuses. Bo Liu Division of Vascular Surgery. Translate inventions in material science to novel treatments for vascular diseases. Clinical problems. Material inventions.
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Division of Vascular Surgery
novel treatments for vascular diseases.
Project I: DNA Carriers
Problem: Lack of safe and efficient DNA/RNA carriers for molecular therapy.
Hypothesis: Newly invented PEA polymers are capable of binding DNA and delivering it to vascular cells and tissues.
Cornell University Seed Grant (Liu & Chu)
Novel biodegradable biomaterials as non-viral gene transfer systems.
15 μg PEA
1,500 μg PEA
15 μg Superfect®
15 μg PEI
Control – no transfection
Novel biodegradable polymers as non-viral gene transfer systems.
Liu, Kent, Rafii, and Chu
Research Fellowship----- 1/01/08 to 12/31/09
Transfection of Vascular Smooth Muscle Cells with Novel Biodegradable Arginine Based Poly(ester-amide)s
Dai Yamanouchi, M.D., Ph.D.,1, Jun Wu,2, Andrew Lazar,1, K Craig Kent, MD.,1, Chih-Chang Chu, Ph.D.,2, Bo Liu, Ph.D.1.
Submitted to Molecular Therapy
Problem: Synthetic arterial grafts fail due to restenosis.
Approach: Using biodegradable materials as scaffold to generate blood vessels ex vivo or in vitro.
Morgan Seed Grant (Chu, Peinhart-King, Liu, and Kent)
Novel biodegradable scaffolds for tissue engineering of blood vessels.
Synthesis of PEA-based biodegradable and biofunctional elastomeric scaffolds
Feedback for optimization of design parameters
Reinhart-King: BMEIn vitro engineering of scaffolds & cell adhesion study using vascular cells
Liu/Kent: WeillMedical Optimization using stem-cell mediated healing to enhance success of engineered grafts
Liu/Kent: WeillMedicalIn vivo animal model & implantation
Enabling Technologies for Tissue Engineering and Regenerative Medicine
Projected submission date: 9/10/08
K. Craig Kent, MD
Bo Liu, PhD
Brad Herman, PhD
Kaori Kato, MD
Rishi Kundi, MD
Sebastian Schuble, MD
Shirling Tsai, MD
Dai Yamanouchi, MD, PhD
Fan Zhang, MD, PhD
C.C. Chu, PhD
Hua Song, PhD
Department of Surgery
Research and Sponsored Program
Caren A Heller, MD
Cornell Intercampus Seed Grant
Morgan Seed grant