Bell Work: 1. Turn in your virus drawing

1. Bell Work: 1. Turn in your virus drawing • Title: Virus Replication • Date 2/4/2016 • EQ: How do viruses replicate? End www.A6training.co.uk

2. What is the drug called that inhibits reverse transcription of HIV? AZT

3. Are Viruses Alive? NO Why? They need a host cell to reproduce

4. No longer accepted:Cladogram HWShark WSFungi WS Taxonomy WS Turn in for 70: Kingdom Sort Due Today: Virus Drawing

5. Quiz Tomorrow!

6. Today’s Standard (B.4C): compare the structures of viruses to cells, describe viral reproduction, and describe the role of viruses in causing diseases such as HIV and influenza.Essential Question: How does a virus reproduce?

7. Essential Question: How does a virus reproduce?Standard: describe viral reproduction (B4C)

8. When a virus invades…

9. Number the ovals on your paper 1 2 6 3 7 4 5 8

10. Lysogenic Cycle

11. Lysogenic Cycle • Attach to cell • Inject DNA/RNA • Integrate/Join virus DNA into cell’s DNA • Wait while cell grows and divides (latency) (Cell is not being destroyed in the lysogenic cycle) • Remove virus DNA/RNA Become active (write on arrow connecting 5 and 6)

12. In the lysogenic cycle the virus become dormant Dormant- having normal physical functions suspended or slowed down for a period of time; in or as if in a deep sleep.

13. - Viruses Lysogenic Cycle

14. Example HIV Write this on the right of your paper (by oval 3) • Enveloped RNA virus • Waits for months to years • Over time the destruction of white blood cells allows people to get sick from other diseases

15. HIV (arrows) Infecting a T-lymphocyte

16. Transmission

17. Create an analogy……… The Lysogenic Cycle is like a ___________ because __________.

18. Lytic Cycle

19. Lytic Cycle • Attach to cell • InjectDNA/RNA • Produce (replicate)virus parts • Assemble new virons • Release viruses to infect other cells (lyse/lysis) (Cell is being destroyed)

20. - Viruses Lytic Cycle

21. Which part of the lytic cycle is shown below?

22. Write this on the right of your paper (by oval 6) Example Influenza A • Enveloped virus with a segmented RNA • Symptoms appear within days • Infects a wide range of animals other than humans • Undergoes extensive mutations • Causes the flu

23. Spread of influenza virus

24. 600 500 400 300 200 100 0 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 Weekly consultation rates for influenza and influenza-like illness: Weekly Returns Service of the Royal College of General Practitioners, 1988 to 1999 Epidemic activity Higher than expected seasonal activity Baseline activity Rate per 100 000 population Normal seasonal activity Year CDR Weekly Report: 5th November 1999

25. Create an analogy……… The Lytic Cycle is like a ___________ because ___________.

27. Sage and Scribe: Cycle Steps • Get into partners—decide who is partner A and who is partner B. • Partner A: Describe the steps for the Lytic cycle. • Partner B: Draw each step. • After a few minutes, we will switch to the Lysogenic Cycle and you will switch roles.

28. Comic Strip • Create a comic strip to describe a viral reproduction cycle. • If you are at a “Red”, you are doing the lysogenic cycle. • If you are at a “Black”, you are doing the lytic cycle. • Your comic should be 6 “slides”, colored, and be the cycle in STORY format