1 / 16

Metabolic Integration and Regulatory Themes in Organ Specialization

Chapter 27 delves into the comprehensive view of metabolic integration through allosteric interactions, covalent modifications, enzyme level adjustments, compartmentalization, and organ specialization for effective control of glycolysis, citric acid cycle, oxidative phosphorylation, and other crucial metabolic pathways.

nowlin
Download Presentation

Metabolic Integration and Regulatory Themes in Organ Specialization

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Integration of MetabolismChapter 27

  2. Regulatory Themes • Allosteric interactions • Covalent modification • Adjustment of enzyme levels • Compartmentalization • Metabolic Specialization of Organs

  3. Control sites • Glycolysis

  4. Control sites • Citric Acid Cycle/Oxidative Phosphorylation • ATP and respiratory control • Pyruvate Dehydrogenase

  5. Control sites • Gluconeogenesis and Pentose Phosphate pathway • PPP and NADPH for reductive biochemistry • F-1,6-Bis phosphatase

  6. Control sites • Glycogen Synthesis/Breakdown • Reciprocal hormone regulation

  7. Control sites • Fatty Acid Synthesis • Citrate • Malonyl CoA and carnitine

  8. Key Junctions in Metabolism

  9. Glucose-6-phosphate

  10. Pyruvate and Acetyl CoA

  11. Metabolic Organ Profiles

  12. Relations between organs Sugars and proteins

  13. Lipid Metabolism

  14. Starvation !!!

More Related