1 / 3

Comparative Analysis of UL26 Proteins in Herpesviruses: Conservation and Variability

This study explores the alignment of N-terminal domains of UL26 homologs across various herpesviruses, including HSV1, VZV, CMV, FPTHV, and LETV. We identify key conserved residues, particularly in histidine domains, highlighting evolutionary relationships and functional implications. By analyzing amino acid sequences, we present a detailed overview of conserved motifs and variable regions, shedding light on potential functional divergences in viral pathogenesis. The results underscore significant evolutionary conservation and variability, promoting further investigation into herpesvirus biology.

norman
Download Presentation

Comparative Analysis of UL26 Proteins in Herpesviruses: Conservation and Variability

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Consensus M A A E A D - X D - - E A - - - - - - - HSV1 UL26 M A A D A P - G D R M E E - - - - - P L 14 VZV ORF33 M A A E A D - E E N C E A - - - - - - - 12 CMV UL80 M T M D E Q - Q S Q A V A P V Y V G - - 17 FPTHV UL26 M Q T E E D - A P - - - - - - - - - - - 8 LETV UL26 M A A E T S Y P D - - - - - - - - - - - 9 Consensus - - - - - - L Y V A G F L A L Y D - - X HSV1 UL26 P D R A V P I Y V A G F L A L Y D - - S 32 VZV ORF33 - - - - - - L Y V A G Y L A L Y S - - K 24 - - - - Supplemental Data Table 2:Alignment of the N-terminal domains of the UL26 homologs of herpes simplex virus 1 (HSV1), human herpesvirus 3 (Varicella-Zoster virus, VZV), human herpesvirus 5 (cytomegalovirus, CMV), FPTHV, and LETV. Highly conserved histidine residues (Liu&Roizman, PNAS 89:2076) are in bold. CMV UL80 - - G F L A R Y D Q S P D - - E 29 FPTHV UL26 - - - - - - L Y V A G F L G L Y D R G G 22 LETV UL26 - - - - - - V Y V G G F L A V Y E - - A 21 Consensus - D E G E L X L D - - - - - - R E I V R HSV1 UL26 G D S G E L A L D - - - - - - P D T V R 46 VZV ORF33 - D E G E L N I T - - - - - - P E I V R 37 CMV UL80 - A E L L L P R D V V E H W L H A Q G Q 48 FPTHV UL26 - E E R G F R L D - - - - - - R E A V R 35 LETV UL26 - D V S E L F L N - - - - - - R E I M A 34

  2. Consensus R A L P L T S X V P L N I D H R A G C V HSV1 UL26 A A L P P D N P L P I N V D H R A G C E 66 VZV ORF33 S A L P P T S K I P I N I D H R K D C V 57 CMV UL80 G Q P S L S V A L P L N I N H D D T A V 68 FPTHV UL26 R G L P L T Q I V P L C I D H K D R C T 55 LETV UL26 R A L P T D S V V P L N I D H R A G C V 54 Consensus V G R V - A X V X D X R G G L F C L G K HSV1 UL26 V G R V L A V V D D P R G P F F - V G L 85 VZV ORF33 V G E V I A I I E D I R G P F F - L G I 76 V G H V CMV UL80 - A A M Q S V R D G L F C L G C 87 FPTHV UL26 V G R V - L S V L D A E K G A F C V A K 74 LETV UL26 V G R V - L T I H N G R Y G L F C L C K 73 Consensus V T S P N L F R V L X E A A D X X X F E HSV1 UL26 I A C V Q L E R V L E T A A S A A I F E 105 VZV ORF33 V R C P Q L H A V L F E A A H S N F F G 96 CMV UL80 V T S P R F L E I V R R A S E K S E L V 107 FPTHV UL26 V T S K N L F R I M L E T V D P R V F E 94 LETV UL26 I T S Q N L F R V M M E T A D E G L F E 93

  3. Consensus N R G P G - - L S E X E K L L Y L I S N HSV1 UL26 R R G P P - - L S R E E R L L Y L I T N 123 VZV ORF33 N R D S V - - L S P L E R A L Y L V T N 114 CMV UL80 S R G P V S P L Q P D K V V E F L S G S 127 FPTHV UL26 - L K P G - - L S E R E K L L L L I S N 111 LETV UL26 N L N P G - - - S E A D K L L Y L I S N 110 Consensus Y L P S V S L S S K R - - - - - - V X S HSV1 UL26 Y L P S V S L A T K R - - - - - - L G G 137 VZV ORF33 Y L P S V S L S S K R - - - - - - L S P 128 Y - A G CMV UL80 L S L S S R R C D D V E A A T S 146 FPTHV UL26 F V P S F S L S S V K - - - - - - V D R 125 LETV UL26 Y I P S F S M S S K R - - - - - - V A S 124 Consensus X E E P D X T F F X H V A L C X V G R R HSV1 UL26 E A H P D R T L F A H V A L C A I G R R 157 VZV ORF33 N E I P D G N F F T H V A L C V V G R R 148 CMV UL80 L S G S E T T P F K H V A L C S V G R R 166 FPTHV UL26 P E E A D E R F F V H V S L C M L G R R 145 LETV UL26 V D E V D S T F V S H V S L C I L G K R 144

More Related